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13 Cards in this Set
- Front
- Back
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What percent of Caucasians are poor metabolizers of what enzyme?
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5-10% of 2D6
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What percent of Asians are poor metabolizers of what enzyme?
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20% 2C19
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Half life refers to concentration in what compartment?
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Plasma
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Steady state is?
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Elimination=absorption
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Clozapine metabolized via
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1a2 2d6 3a4
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Olanzapine metabolized via
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1a2 2d6 glucoronidation
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Risperidone metabolized via
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2d6; metabolite equipotent
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Seroquel and Geodon metabolized via
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3a4
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Inhibitor of 1a2
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Fluvoxamine grapefruit juice
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Inducer if 1a2
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Cigarettes
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Inhibitor of 2d6
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SSRI esp. Fluoxetine, paxil, high dose Zoloft
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Inhibitor 3a4
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Macrolides
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Inducer of 3a2
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Tegretol Dilantin barbiturates glucocorticoids
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