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61 Cards in this Set
- Front
- Back
Oral contraceptives interact with which antibiotics
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Penicillins, cephalosporins, tetracyclines, ciprofloxacin
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Erythromycin and clarithromycin interferes with the metabolism of which 3 drugs
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Carbamazepine, cyclosporine, and warfarin
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Erythromycin and clarithromycin interacts with what one drug that can possibly cause rhabdomyolysis
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HMG-CoA reductase inhibitors (statins)
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Metronidazole alters the metabolism of ___ leading to a buildup of acetaldehyde
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alcohol
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Metronidazole interacts with ___ and ___ such that the hepatic clearance of metronidazole is decreased
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Cimetidine and warfarin
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Metronidazole interacts with which 2 drugs such that the hepatic clearance of metronidazole is increased
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barbiturates, phenytoin
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Metronidazole may decrease which drug?
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PHENYTOIN
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Metronidazole interacts with ___ such that renal toxicity of ___ may occur
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Lithium salts, Li+ salts
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Aspirin and other NSAIDs interact with ___ drugs such that hypoglycemic effects are enhanced. Substitute with acetaminophen
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Antidiabetic sulfonylurea drugs
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Plasma concentrations of these 5 drugs are increased by aspirin-like drugs. Substitute with acetominophen
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Baclofen, methetrexate, Lithium salts, phenytoin, Ca++ channel blockers
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____ interferes with renal and biliary excretion of NSAIDs
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Probenecid
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Aspirin may block the uricosuric effects of ___ and ___. Substitute with acetaminophen
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Probenecid and sulfinpyrazone
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Combination of these 2 things with Aspirin may result in GI ulceration and bleeding
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Alcohol, corticosterioid and Aspirin/NSAIDs
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Hypotensive effect of ACE inhibitors, beta blockers and diuretics maybe be reduced with ___.
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Aspirin and other NSAIDs
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Aspirin/other NSAIDs and acetaminophen with ___ may increase bleeding
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anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics
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Aspirin and ___ may increase bleeding.
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Valproic Acid
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Ibuprofen decreases clearance of ___. Substitute aceaminophen to avoid toxicity
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Digoxin
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Acetaminophen hepatoxicity is more likely in chronic ___
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Alcoholics
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These 5 things might alter the metabolism of acetaminophen.
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Beta blockers, barbiturates, isoniazid, phenytoin, sulfinpyrazone
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Opioids increase the effects of these drugs.
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Antimuscarinics, antidiarrheals, antihypertensives
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These drugs block the analgesic effects of opioids. Substitute with ibuprofen or similar NSAID for pain relief
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Naltrexone, opioid agonist-antagonist
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______results in marked toxicity with these drugs and is absolutely contraindicated.
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Meperidine....with these drugs: MOA inhibitors, furazolidone, procarbazine
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These drugs may increase the plasma concentrations and effects of the opioids.
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Aprepitant, diltiazem, ketoconazole, HIV protease inhibitors, verapamil
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Codeine, hydrocodone, oxycodone is not good with what 5 drugs
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Fluoxetine, paroxetine, quinidine, retonavir, sertraline (because the conversion to analgesic metabolites may be impaired. Avoid use of codeine.)
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Propoxyphene with what 4 drugs is bad. Propoxyphene inhibits the metabolism of these agents
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Alprazolam, carbamazepine, doxepin, warfarin
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Carbamazepine interacts with which 2 drugs
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Erythromycin and clarithromycin
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Cyclosporine interacts with which 2 drugs
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Erythromycin and clarithromycin
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Warfarin interacts with which drugs
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Erythromycin, clarithromycin, metronidazole, propoxyphene
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Everything that's not good with metronidazole
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Alcohol, cimetidine, barbituates, phenytoin, Li+ salts, warfarin
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Phenytoin is not good with
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Metronidazole, Aspirin and other NSAIDs, acetaminophen,
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Everything that Aspirin and other NSAIDs are not good with
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Antidiabetic sulfonylurea drugs, Baclofen, methetrexate, Li+ salts, phenytoin, Ca++ blockers, Probenecid, Sulfinpyrazone, Alcohol, corticosterioid, ACE inhibitors, beta blockers, diuretics, anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics
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Only aspirin is not good with
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Valproic Acid
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Acetominophen is not good with
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Anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics, alcohol, beta blockers barbituates ,isoniazid, phenytoin, sulfinpyrazone
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Only Ibuprofen is not good with
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Digoxin
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Opioids are not good with
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Antimuscarinics, antidiarrheals, antihypertensives, Naltrexone, opioid agonist/antagonists, Monoamine oxidase inhibitors, furazolidone, procarbazine, Aprepitant, diltiazem, ketoconazole, HIV protease inhibitors, verapamil
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Fluoxetine, paroxetine, Sertraline are not good with
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Codeine, hydrocodone, oxycodone
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Quinidine and retonavir is not good with
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Codeine, hydrocodone, oxycodone
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Alprazolam, carbamazepine, doxepin, warfarin are not good with
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Propoxyphene
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Local anesthetics are not good with
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Antiarrhytmic drugs (increased cardiac depression), anticholineresterases (LA may antagonize the effects of acetylcholinesterase inhibitors on muscle contractility. Treat myasthenia patients in consultation)
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Amides interact with
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Amiodarone, beta blockers, cimetidine
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Esters do not go well with
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Sulfonamides (inhibition of sulfonamides may occur)
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Adrenergic vasoconstrictors do not go well with
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Inhalation anesthetics, methyldopa, TCA, beta blockers, adrenergic neuron blockers, entacapone, tolcapone, antipsychotics
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Benzodiazepine interacts with
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H2 antihistamines, carbamazepine, disulfiram, lflruoxetine, ketoconazole, isoniazid, itraconazole, metoprolol, omeprazole, oral contraceptives, propanolol, probenecid, valproic acid, levodopa, amiodarone, digoxin
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Ketoconazole interacts with
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Benzodiazepine, proton pump inhibitors, opioids, midazolam, triazolam
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Isoniazid interacts with
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Benzodiazepines, acetominophen
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Valproic acid is not good with
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Benzodiazepine and Aspirin
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Carbamazepine is not good with
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Erythromycin, clarithromycin, propoxyphene, benzodiazepines
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Amiodarone is not good with
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Benzodiazepines, amides,
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Cimitidine interacts with
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Midazolam, traizolam, metronidazole, amides
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Midazolam and Triazolam interacts with
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Diltiazem, cimetidine, erythromycin, fluoxetine, fluvoxamine, ketoconazole, itraconazole, quinupristin/dalfopristin, nefazodone, verapamil, clozapine, HIV protease inhibitors
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St. John's Worts interacts with
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Amitrytillline, Anticonvulsants, Antihistamines, benzodiazepine, Ca++ channel blockers, chemotherapy, oral contraception, digoxin, simvastatin, SSRI, Warfarin
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Milk Thistle interacts with
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Metronidazole
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Black cohosh interacts with
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Iron, hormones, warfarin, salivylates
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Echinacea interacts with
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immunosuppressants
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Gingko interacts with
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Tylenol, anticonvulsants, antidepressants, aspirin, thiazides
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Garlic interacts with
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Aspirin, HIV med, warfarin
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Cranberry and soy
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low interaction
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Coenzyme 10 interacts with
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Warfarin by decreasing warfarin's effects
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What is coenzyme Q10 used for
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Hypertension, heart failure, ischemic heart dz, prevention of statin induced myopathy
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Glucosamine interacts with
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Increasing INR in patients taking warfarin
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Melatonin interacts with
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NSAIDs, antidepressants, beta agonists and antagonists, scopolamine, Na vlaproate, Nifedipine (which will increase BP and heart rate)
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