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61 Cards in this Set

  • Front
  • Back
Oral contraceptives interact with which antibiotics
Penicillins, cephalosporins, tetracyclines, ciprofloxacin
Erythromycin and clarithromycin interferes with the metabolism of which 3 drugs
Carbamazepine, cyclosporine, and warfarin
Erythromycin and clarithromycin interacts with what one drug that can possibly cause rhabdomyolysis
HMG-CoA reductase inhibitors (statins)
Metronidazole alters the metabolism of ___ leading to a buildup of acetaldehyde
alcohol
Metronidazole interacts with ___ and ___ such that the hepatic clearance of metronidazole is decreased
Cimetidine and warfarin
Metronidazole interacts with which 2 drugs such that the hepatic clearance of metronidazole is increased
barbiturates, phenytoin
Metronidazole may decrease which drug?
PHENYTOIN
Metronidazole interacts with ___ such that renal toxicity of ___ may occur
Lithium salts, Li+ salts
Aspirin and other NSAIDs interact with ___ drugs such that hypoglycemic effects are enhanced. Substitute with acetaminophen
Antidiabetic sulfonylurea drugs
Plasma concentrations of these 5 drugs are increased by aspirin-like drugs. Substitute with acetominophen
Baclofen, methetrexate, Lithium salts, phenytoin, Ca++ channel blockers
____ interferes with renal and biliary excretion of NSAIDs
Probenecid
Aspirin may block the uricosuric effects of ___ and ___. Substitute with acetaminophen
Probenecid and sulfinpyrazone
Combination of these 2 things with Aspirin may result in GI ulceration and bleeding
Alcohol, corticosterioid and Aspirin/NSAIDs
Hypotensive effect of ACE inhibitors, beta blockers and diuretics maybe be reduced with ___.
Aspirin and other NSAIDs
Aspirin/other NSAIDs and acetaminophen with ___ may increase bleeding
anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics
Aspirin and ___ may increase bleeding.
Valproic Acid
Ibuprofen decreases clearance of ___. Substitute aceaminophen to avoid toxicity
Digoxin
Acetaminophen hepatoxicity is more likely in chronic ___
Alcoholics
These 5 things might alter the metabolism of acetaminophen.
Beta blockers, barbiturates, isoniazid, phenytoin, sulfinpyrazone
Opioids increase the effects of these drugs.
Antimuscarinics, antidiarrheals, antihypertensives
These drugs block the analgesic effects of opioids. Substitute with ibuprofen or similar NSAID for pain relief
Naltrexone, opioid agonist-antagonist
______results in marked toxicity with these drugs and is absolutely contraindicated.
Meperidine....with these drugs: MOA inhibitors, furazolidone, procarbazine
These drugs may increase the plasma concentrations and effects of the opioids.
Aprepitant, diltiazem, ketoconazole, HIV protease inhibitors, verapamil
Codeine, hydrocodone, oxycodone is not good with what 5 drugs
Fluoxetine, paroxetine, quinidine, retonavir, sertraline (because the conversion to analgesic metabolites may be impaired. Avoid use of codeine.)
Propoxyphene with what 4 drugs is bad. Propoxyphene inhibits the metabolism of these agents
Alprazolam, carbamazepine, doxepin, warfarin
Carbamazepine interacts with which 2 drugs
Erythromycin and clarithromycin
Cyclosporine interacts with which 2 drugs
Erythromycin and clarithromycin
Warfarin interacts with which drugs
Erythromycin, clarithromycin, metronidazole, propoxyphene
Everything that's not good with metronidazole
Alcohol, cimetidine, barbituates, phenytoin, Li+ salts, warfarin
Phenytoin is not good with
Metronidazole, Aspirin and other NSAIDs, acetaminophen,
Everything that Aspirin and other NSAIDs are not good with
Antidiabetic sulfonylurea drugs, Baclofen, methetrexate, Li+ salts, phenytoin, Ca++ blockers, Probenecid, Sulfinpyrazone, Alcohol, corticosterioid, ACE inhibitors, beta blockers, diuretics, anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics
Only aspirin is not good with
Valproic Acid
Acetominophen is not good with
Anticoagulants, thrombolytics, broad spectrum beta-lactam antibiotics, alcohol, beta blockers barbituates ,isoniazid, phenytoin, sulfinpyrazone
Only Ibuprofen is not good with
Digoxin
Opioids are not good with
Antimuscarinics, antidiarrheals, antihypertensives, Naltrexone, opioid agonist/antagonists, Monoamine oxidase inhibitors, furazolidone, procarbazine, Aprepitant, diltiazem, ketoconazole, HIV protease inhibitors, verapamil
Fluoxetine, paroxetine, Sertraline are not good with
Codeine, hydrocodone, oxycodone
Quinidine and retonavir is not good with
Codeine, hydrocodone, oxycodone
Alprazolam, carbamazepine, doxepin, warfarin are not good with
Propoxyphene
Local anesthetics are not good with
Antiarrhytmic drugs (increased cardiac depression), anticholineresterases (LA may antagonize the effects of acetylcholinesterase inhibitors on muscle contractility. Treat myasthenia patients in consultation)
Amides interact with
Amiodarone, beta blockers, cimetidine
Esters do not go well with
Sulfonamides (inhibition of sulfonamides may occur)
Adrenergic vasoconstrictors do not go well with
Inhalation anesthetics, methyldopa, TCA, beta blockers, adrenergic neuron blockers, entacapone, tolcapone, antipsychotics
Benzodiazepine interacts with
H2 antihistamines, carbamazepine, disulfiram, lflruoxetine, ketoconazole, isoniazid, itraconazole, metoprolol, omeprazole, oral contraceptives, propanolol, probenecid, valproic acid, levodopa, amiodarone, digoxin
Ketoconazole interacts with
Benzodiazepine, proton pump inhibitors, opioids, midazolam, triazolam
Isoniazid interacts with
Benzodiazepines, acetominophen
Valproic acid is not good with
Benzodiazepine and Aspirin
Carbamazepine is not good with
Erythromycin, clarithromycin, propoxyphene, benzodiazepines
Amiodarone is not good with
Benzodiazepines, amides,
Cimitidine interacts with
Midazolam, traizolam, metronidazole, amides
Midazolam and Triazolam interacts with
Diltiazem, cimetidine, erythromycin, fluoxetine, fluvoxamine, ketoconazole, itraconazole, quinupristin/dalfopristin, nefazodone, verapamil, clozapine, HIV protease inhibitors
St. John's Worts interacts with
Amitrytillline, Anticonvulsants, Antihistamines, benzodiazepine, Ca++ channel blockers, chemotherapy, oral contraception, digoxin, simvastatin, SSRI, Warfarin
Milk Thistle interacts with
Metronidazole
Black cohosh interacts with
Iron, hormones, warfarin, salivylates
Echinacea interacts with
immunosuppressants
Gingko interacts with
Tylenol, anticonvulsants, antidepressants, aspirin, thiazides
Garlic interacts with
Aspirin, HIV med, warfarin
Cranberry and soy
low interaction
Coenzyme 10 interacts with
Warfarin by decreasing warfarin's effects
What is coenzyme Q10 used for
Hypertension, heart failure, ischemic heart dz, prevention of statin induced myopathy
Glucosamine interacts with
Increasing INR in patients taking warfarin
Melatonin interacts with
NSAIDs, antidepressants, beta agonists and antagonists, scopolamine, Na vlaproate, Nifedipine (which will increase BP and heart rate)