Drug Delivery -L2

Front 1

which of the following can result in an electrolyte solution
1.DNA
2.polypeptides
3.synthetic polymers
4.Salts,
5.acids and bases

Back 1

all

Front 2

Equivalence conductance equation

Back 2

Equivalence conductance
Λc = κ V = 100 κ / c

Front 3

What makes the observed colligative properties to be less than expected in concentrated solutions of strong electrolyte solutions

Back 3

Ionic association prevents complete dissociation because of ion pair formation
a=gama c

Front 4

BrÖnsted-Lowry Theory

Back 4

Acid: capable of donating a proton

Base: capable of accepting a proton

Front 5

Lewis Electronic Theory

Back 5

Acid: can accept an electron pair to form a covalent bond

Base: can donate a pair of unshared electrons

Front 6

The basicity constant of morphine is 7.4 x 10-7 at 250C.
What is the pH of a 0.0005 M aqueous solution of morphine?

Back 6

9.28

Front 7

What is the concentration of dissociated and undissociated
acetic acid in a pH 4 solution (Ka=1.75E-5)?

Back 7

5.7 10e-4

Front 8

which type of solution has this characteristic-Ideal or Real solution?
no heat evolved or absorbed

Back 8

Ideal solution

Front 9

finished dosage forms or drug delivery systems which contain the API along with excipients/inert substances

Back 9

drug produt

Front 10

The drug/component that produces pharmacological activity.

Back 10

API.

Front 11

major attributes of drug delivery system

Back 11

• Maximum efficacy, safety, reliability and stability
• Control the rate of drug delivery
• Release drug at target (disease) site
• Contain high concentration of drug dispersion in the system
• Applicable to a wide range and variety of drugs

Front 12

the slowest rate in the entire drug bioavailability process

Back 12

rate-limiting step.

Front 13

which step of the rate process of drug bioavailability is entirely controlled by excipients?

Back 13

Disintegration

Front 14

True or false.Increase particle surface area helps to increase rate of dissolution and consequently, oral absorption.

Back 14

True

Front 15

refers to arrangement of the same drug in different crystal forms

Back 15

Polymorphism

Front 16

True or False.Hydrates (or solvates) are crystalline and less-soluble than the more amorphous (anhydrous) forms of drugs.

Back 16

True

Front 17

determines the drug’s ability to absorb moisture from the environment

Back 17

Hygroscopicity

Front 18

the science of powders and small particles.

Back 18

micromeritics

Front 19

true /false.
the solubility of an acid increases with increased ph.

Back 19

true

Front 20

Identify the incorrect Strategies and techniques to improve drug solubility
A.Change from amorphous to crystalline
B.Change from anhydrous to hydrate (hydrous form)
C.Increase particle size
D.All

Back 20

ALL

Front 21

Is an inactive bioreversible derivative of the active drug.

Back 21

Prodrug

Front 22

Natural products from the bacterial digestion of cellulose which have tremondus use in complexation of drugs

Back 22

Cyclodextrins

Front 23

are polymers that are capable of exchanging particular ions within the polymer with ions in a solution that is passed through them.

Back 23

Ion exchange resins

Front 24

This complex formation is commionly used used for controlled drug-delivery

Back 24

Ion-exchange

Front 25

Two most frequently encountered causes of degradations are----------&---------

Back 25

hydrolysis and oxidation

Front 26

These are reactions in which degradation (or formation) of drug with respect to time, is independent of concentration of reactants

Back 26

Zero-Order Rate

Front 27

Equation of a zero order rate degradation

Back 27

C=(-)Ko(t)+Co

Front 28

A process of Increasing surface area

Back 28

Micronization

Front 29

Strategies of increasing Solubility

Back 29

Reducing partcle size ,heat, using a solubilizing agent (eg., ethanol), and/or agitation