Drug Class - Antiulcer

Front 1

Name 4 groups of antiulcer agents?

Back 1

antacids
histamine H2 antagonists
proton-pump inhibitors
miscellaneous

Front 2

Name 3 antacids?

Back 2

aluminum hydroxide
AlternaGEL, Alu-Cap, {Alugel}, Aluminet, Alu-Tab, Amphojel, Basal-gel, Dialume

magaldrate
{Losopan}, Lowsium, Riopan,
{Riopan Extra Strength}

magnesium hydroxide/aluminum
hydroxide
Alamag, {Diovol}, {Diovol Ex}, {Gelusil}, {Gelusil Extra Strength}, Maalox, Maalox TC, Mintox, Mylanta Double Strength, {Neutralca-S}, Rulox, Rulox No.1, Rulox No. 2

Front 3

Name 5 histamine H2 antagonists?

Back 3

cimetidine {Apo-Cimetidine},
{Novocimetine}, {Peptol}, Tagamet, Tagamet HB

famotidine Mylanta AR, Pepcid, Pepcid AC, Pepcid AC Acid Controller, {Pepcid RPD}

nizatidine Axid, Axid AR

ranitidine bismuth citrate
Tritec

ranitidine Zantac 75

Front 4

Name 4 proton-pump inhibitors?

Back 4

esomeprazole Nexium
lansoprazole Prevacid
omeprazole Losec, Prilosec
rabeprazole Aciphex

Front 5

Name 9 miscellaneous antiulcer agents?

Back 5

amoxicillin Amoxil, {Apo-Amoxil}, DisperMox, {Novamoxin}, {Nu-Amoxi}, Trimox

bismuth subsalicylate
Bismatrol, Bismed, Kaopectate, Peptobismol, Pink Bismuth, {PMS-Bismuth Subsalicylate}

clarithromycin
Biaxin, Biaxin XL

metronidazole
{Apo-Metronidazole}, Flagyl, Flagyl ER, Metric 21, MetroCream, MetroGel, MetroGel-Vaginal, MetroLotion, Metro IV, Metryl, {Nidagel}, Noritate, {Novonidazol}, Protostate, {Trikacide}

misoprostol
Cytotec

pantoprazole
Protonix, Protonix IV

propantheline

sodium bicarbonate
Baking soda, Bell-Ans, Citrocarbonate, Neut, Soda Mint

sucralfate

Front 6

General use for antiulcer agents are?

Back 6

treatment and prophylaxis of peptic ulcer and gastric hypersecretory conditions such as Zollinger-Ellison syndrome.

Front 7

Which 2 groups of antiulcer agents are used to manage GERD?

Back 7

histamine H2-receptor
antagonists (blockers)
proton pump inhibitors

Front 8

A great majority of peptic ulcer disease may be traced to 1____ infection with the organism 2_______ ______.

Back 8

1. GI
2. Helicobacter pylori

Front 9

Eradication of _____ ______ microorganism decreases symptomotology and recurrence.

Back 9

Helicobacter pylori

Front 10

Anti-infectives with significant activity against the organism H. pylori include?

Back 10

amoxicillin
clarithromycin
metronidazole
tetracycline

Front 11

The miscellaneous antiulcer agent _____ ______ also has anti-infective activity against H. pylori.

Back 11

bismuth subsalicylate

Front 12

Regimens usually include? (2)

Back 12

a histamine H2-receptor
antagonist
OR
a proton pump inhibitor and 2 anti-infectives with or without bismuth subsalicylate for 1-14 days

Front 13

Other medications used in the management of gastric-duodenal ulcer disease are aimed at? (3)

Back 13

neutralizing gastric acid
(antacids)
decreasing acid secretion
(histamine H2 antagonists,
proton pump inhibitors,
misoprostol)
protecting the ulcer surface
from further damage
(misoprostol, sucralfate)

Front 14

The ______ neutralize gastric acid.

Back 14

antacids

Front 15

Histamine H2 antagonists, proton pump inhibitors, and misoprostol work by? (1)

Back 15

decreasing acid secretion

Front 16

Misoprostal and sucralfate protect the ulcer surface from? (1)

Back 16

further damage

Front 17

Histamine H2-receptor antagonists competitively inhibit the action of histamine at the H2 receptor, located primarily in _____ _____ ______, resulting in inhibition of gastric acid secretion.

Back 17

gastric parietal cells

Front 18

Which agent decreases gastric acid secretion and increases production of protective mucus.

Back 18

Misoprostal

Front 19

____ ____ _____ prevent the transport of hydrogen ions into the gastric lumen.

Back 19

Proton pump inhibitors

Front 20

______ is a contraindication.

Back 20

hypersensitivity

Front 21

Most ______ ______ ______ require dosage reduction in renal impairment and in elderly patients.

Back 21

histamine H2 antagonists

Front 22

_______-containing antacids should be used cautiously in patients with renal impairment.

Back 22

magnesium

Front 23

________ should be used cautiously in women with childbearing potential.

Back 23

misoprostol

Front 24

Calcium- and magnesium-containing antacids decrease the absorption of _____ and _____.

Back 24

tetracycline
fluoroquinolones

Front 25

______ inhibits the ability of the liver to metabolize several drugs, increasing the risk of toxicity from warfarin, tricyclic antidepressants, theophylline, metoprolol, phenytoin, propranolol, and lidocaine.

Back 25

cimetidine

Front 26

_______ decreases metabolism of phenytoin, diazepam, and warfarin.

Back 26

omeprazole

Front 27

All agents that increase gastric pH will decrease the absorption of ______.

Back 27

ketoconazole

Front 28

Calcium- and magnesium-containing antacids decrease the absorption of _____ and _____.

Back 28

tetracycline
fluoroquinolones

Front 29

______ inhibits the ability of the liver to metabolize several drugs, increasing the risk of toxicity from warfarin, tricyclic antidepressants, theophylline, metoprolol, phenytoin, propranolol, and lidocaine.

Back 29

cimetidine

Front 30

_______ decreases metabolism of phenytoin, diazepam, and warfarin.

Back 30

omeprazole

Front 31

All agents that increase gastric pH will decrease the absorption of ______.

Back 31

ketoconazole