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31 Cards in this Set

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Name 4 groups of antiulcer agents?
antacids
histamine H2 antagonists
proton-pump inhibitors
miscellaneous
Name 3 antacids?
aluminum hydroxide
AlternaGEL, Alu-Cap, {Alugel}, Aluminet, Alu-Tab, Amphojel, Basal-gel, Dialume

magaldrate
{Losopan}, Lowsium, Riopan,
{Riopan Extra Strength}

magnesium hydroxide/aluminum
hydroxide
Alamag, {Diovol}, {Diovol Ex}, {Gelusil}, {Gelusil Extra Strength}, Maalox, Maalox TC, Mintox, Mylanta Double Strength, {Neutralca-S}, Rulox, Rulox No.1, Rulox No. 2
Name 5 histamine H2 antagonists?
cimetidine {Apo-Cimetidine},
{Novocimetine}, {Peptol}, Tagamet, Tagamet HB

famotidine Mylanta AR, Pepcid, Pepcid AC, Pepcid AC Acid Controller, {Pepcid RPD}

nizatidine Axid, Axid AR

ranitidine bismuth citrate
Tritec

ranitidine Zantac 75
Name 4 proton-pump inhibitors?
esomeprazole Nexium
lansoprazole Prevacid
omeprazole Losec, Prilosec
rabeprazole Aciphex
Name 9 miscellaneous antiulcer agents?
amoxicillin Amoxil, {Apo-Amoxil}, DisperMox, {Novamoxin}, {Nu-Amoxi}, Trimox

bismuth subsalicylate
Bismatrol, Bismed, Kaopectate, Peptobismol, Pink Bismuth, {PMS-Bismuth Subsalicylate}

clarithromycin
Biaxin, Biaxin XL

metronidazole
{Apo-Metronidazole}, Flagyl, Flagyl ER, Metric 21, MetroCream, MetroGel, MetroGel-Vaginal, MetroLotion, Metro IV, Metryl, {Nidagel}, Noritate, {Novonidazol}, Protostate, {Trikacide}

misoprostol
Cytotec

pantoprazole
Protonix, Protonix IV

propantheline

sodium bicarbonate
Baking soda, Bell-Ans, Citrocarbonate, Neut, Soda Mint

sucralfate
General use for antiulcer agents are?
treatment and prophylaxis of peptic ulcer and gastric hypersecretory conditions such as Zollinger-Ellison syndrome.
Which 2 groups of antiulcer agents are used to manage GERD?
histamine H2-receptor
antagonists (blockers)
proton pump inhibitors
A great majority of peptic ulcer disease may be traced to 1____ infection with the organism 2_______ ______.
1. GI
2. Helicobacter pylori
Eradication of _____ ______ microorganism decreases symptomotology and recurrence.
Helicobacter pylori
Anti-infectives with significant activity against the organism H. pylori include?
amoxicillin
clarithromycin
metronidazole
tetracycline
The miscellaneous antiulcer agent _____ ______ also has anti-infective activity against H. pylori.
bismuth subsalicylate
Regimens usually include? (2)
a histamine H2-receptor
antagonist
OR
a proton pump inhibitor and 2 anti-infectives with or without bismuth subsalicylate for 1-14 days
Other medications used in the management of gastric-duodenal ulcer disease are aimed at? (3)
neutralizing gastric acid
(antacids)
decreasing acid secretion
(histamine H2 antagonists,
proton pump inhibitors,
misoprostol)
protecting the ulcer surface
from further damage
(misoprostol, sucralfate)
The ______ neutralize gastric acid.
antacids
Histamine H2 antagonists, proton pump inhibitors, and misoprostol work by? (1)
decreasing acid secretion
Misoprostal and sucralfate protect the ulcer surface from? (1)
further damage
Histamine H2-receptor antagonists competitively inhibit the action of histamine at the H2 receptor, located primarily in _____ _____ ______, resulting in inhibition of gastric acid secretion.
gastric parietal cells
Which agent decreases gastric acid secretion and increases production of protective mucus.
Misoprostal
____ ____ _____ prevent the transport of hydrogen ions into the gastric lumen.
Proton pump inhibitors
______ is a contraindication.
hypersensitivity
Most ______ ______ ______ require dosage reduction in renal impairment and in elderly patients.
histamine H2 antagonists
_______-containing antacids should be used cautiously in patients with renal impairment.
magnesium
________ should be used cautiously in women with childbearing potential.
misoprostol
Calcium- and magnesium-containing antacids decrease the absorption of _____ and _____.
tetracycline
fluoroquinolones
______ inhibits the ability of the liver to metabolize several drugs, increasing the risk of toxicity from warfarin, tricyclic antidepressants, theophylline, metoprolol, phenytoin, propranolol, and lidocaine.
cimetidine
_______ decreases metabolism of phenytoin, diazepam, and warfarin.
omeprazole
All agents that increase gastric pH will decrease the absorption of ______.
ketoconazole
Calcium- and magnesium-containing antacids decrease the absorption of _____ and _____.
tetracycline
fluoroquinolones
______ inhibits the ability of the liver to metabolize several drugs, increasing the risk of toxicity from warfarin, tricyclic antidepressants, theophylline, metoprolol, phenytoin, propranolol, and lidocaine.
cimetidine
_______ decreases metabolism of phenytoin, diazepam, and warfarin.
omeprazole
All agents that increase gastric pH will decrease the absorption of ______.
ketoconazole