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7 Cards in this Set
- Front
- Back
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How do drugs alter neuronal conduction? |
• tetrodotoxin blocks sodium channels • Neuro toxins (scorpions sea anemones) keep sodium channels open |
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What are the 5 steps of synaptic neurotransmission? |
1. Synthesis 2. Neurotransmitter packaging 3. Neurotransmitter release 4. Receptor action ( postsynaptic neuron, Auto receptor 5. Inactivation |
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How do drugs affect synthesis? |
• some drugs increase synthesis- agonist (Parkinson's disease and L dopa) • some drugs decrease synthesis- antagonist (AMPT) |
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How do drugs affect packaging in synaptic best? |
Block storage (reserpine causes leakage) |
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How do drugs affect neurotransmitter release? |
• drugs facilitate release-aganist (black widow spider) facilitates the release of Ach • drugs block release-antagonist (Botox) blocks the release of Ach |
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How do drugs affect receptors |
• in the postsynaptic receptors drugs bind and activate (nicotine)-agonist • bind and block (belladonna) antagonist • they can block and activate out of receptors |
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How do drugs affect Nero transmitter inactivation? |
• block breakdown (Sarin, myasthenia gravis, Aricept, Donepezil) • block reuptake (cocaine) |
