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7 Cards in this Set
- Front
- Back
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What are the signs of Depression?
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- loss of interest in pleasurable activity, changes in appetite, disturbances in sleep, depressed mood, loss of energy and suicidal thoughts
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What are the signs of Manic depression?
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increased interest in pleasurable activity, decreased sleep, increased talkatativeness, distractibility,inflated self-esteem
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What is the mechanism of action of anti-depressants?
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they arise from defects in neurotransmission at dopamine, serotonin and norepinephrene
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What are the classes of antidepressents?
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1. Tricyclic compounds
2. Monoamine oxidase inhibitors 3. Dopamine reuptake inhibitors 4. Selective Serotonin re-uptake inhibitors 5.Serotonin- Norpenephrine re-uptake inhibitors |
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What are the effects of tricyclic antidepressants?
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- do not elevate mood or arousal in healthy patients (actually cause fatigue)
- rise in patient modd & interest in activities after 2-4 weeks - potent inhibitors of norphenephrine and serotonin receptors - downegulate beta adrogenric receptors and sensitize postsynaptic serotonergic receptors examples: desipramine (Norpramin, imipramine (Tofranil) & notripytline (Aventyl) |
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What is an example of monoamine oxidase?
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-iproniazid
-inhibits MAO A & B but A is more important in relieveing depression -works after 2-3 weeks - increases 5-HT, NE and DA but increase in 5-HT is most important |
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What is the side effects of MAOIS and TCAS?
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- excessive CNS stimulation
- peripheral vascular effects - atropine effects (dry mouth, constipation, disturbances imbalance between sympathetic and vagal tone |
