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12 Cards in this Set
- Front
- Back
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What is the most important transport mechanism for drugs?
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passive diffusion
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What are 3 characteristics of drugs that influence their movement across membranes?
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lipid solubility, ionization, protein binding
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What is the lipid to water partition coefficient?
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ratio of the drug dissolved in lipid vs the drug dissolved in water
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What term is used to quantify the lipid solubility of drugs?
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lipid/water partition coefficient
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Which enteral drug absorption locations bypass the liver?
Which enteral (gastrointestinal tract) section is most important in drug delivery |
rectum and oral cavity
small intestine |
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Rank the following in terms of speed:
intravenous,subcutaneous, intramusuclar |
IV > intramuscular > subQ
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What is the ionization constant for a weak acid? for a weak base?
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Ka = [H+][A-]/[HA]
Ka = [H+][B]/[HB+] |
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what is the henderson hasselbach equation for a weak acid? weak base?
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A: pH = pKA + log [A-]/[HA]
B: pH = pKa + log [B] / [BH+] |
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Ion trapping?
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the highest concentration of ions will be in the compartment in which the greatest degree of ionization occurs
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Volume of distribution (Vd)?
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the theoretical volume in which the total amount of drug is distributed to produce the desired blood concentration of a drug
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What is the apparent volume of the body?
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40 L
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When doing a balancing equation with plasma and stomach or two different things, what do you set equal to each other?
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non charged component of either acid or base
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