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37 Cards in this Set
- Front
- Back
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mechloretamine |
-nitrogenmustard - alkylating agent - decrease in bone marroe cells and wbc - ;ymphoma and leukemia IV near tumor cytotox non cell cyce specific , kills rapidly diving cells |
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cyclophosphamide |
stable nirogen mustard - alkalating agent activated metabolically by liver , cyto p450 into aldehy metabolite - forms acrlein (toxic) DNA damage + crosslinking - alkalates N7 of guanine - works as immunosuppressant |
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cisplastin |
small organoplatnum compound - aklating agent -cross linking DNA non cell cycle specific : causes NV, nephrotox, ototox |
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methotrexae |
antimetabolite - antibacterial drug similar to folic acid inhibits DHFR (similar to trimethoprim) - mamalian enzyme - starves cells of thymidine , resistance: impaired transport, inpared polyglutamate formation, altered affinity to dhfr, decrease thymidylate synthease |
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5-fu |
pyrimidine analog , anti metabolite inhibits thymadylate synthhase --> damages DNA and RNA |
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cytarabine ( AraC) |
changes sugar instead of base, antimetabolite, arabinose sugar inhibits DNA polymerase and causes chain termination resistance: can converte and inactivate |
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vincristine |
vinca alkaloids - target microtubules , prevent assembl of tubulin |
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vinblastine |
causes myleosuppression, vinca alkaloids, targets microtubules |
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taxol/ taxanes |
diassembly of microtubules abrazane |
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etoposide |
topoisomerase inhibitors modify prtens -> DNA damage --> DNA strand breaks cell cycle specific: S and G2 |
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doxorubicin |
anthracyclines anti tumor antibiotics - blocks DNA and RNA synthesises, ihibits topoisomerase 2, alters cell memb fluidity and ion transport generates free radicals-> oxidative stress |
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bleomycin |
anti tumor antibiotics causes DNA single strand breaks and double strand braks inhibits synthesis in G2 phase could be an alkylating agent |
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prednisone |
glucocorticoid action - affects expression of genes turned on by binding f the glucocorticoid receptor to their promoter ( anti inflam + cell death) antilympocytic effects + apoptosis |
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tamoxifen |
blocks estrogen receptor - decrease prolferation - competitice partia agonist antagonist supresses IGF1 and upregulates TGF B |
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anastrozole |
blocks synthesis of estrogen , removing receptors stimulus proliferation , aromatase inhibitors ( converts testosterone to estradiol) |
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flutamide |
blocks androgen action by blocking receptor-> decreasing stimuls and proliferation |
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finasteride |
blocks androgen action - blocks 5a reductase - concerts t to active androgen (DHT) |
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gonadoroping releasing hormone agonist |
GnRH agonists - supress release of gonadotropin -> hypogonadism shuts of HPAaxis |
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L-asparaginase |
asparaginase to aspartic acid blocks protein synthesis in acute lymphoblastic leukemia |
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imatinib |
tyrosine kinase inhibitor blocks active site of kinase preventing substrate from entering active site -> blocks translocation in chronic myelogenous leukemia (CML) |
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trastuzumab
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monoclonal antibody that inhibits activation of HER2 -> blocks kinase cascade -> cell death |
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bevacizumab |
blocks angiogenesis - monoclonal antibody that targets vascular endothelial growth (VEGF A) - stops tumor growth |
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retinoid acid |
rminal differentiation of leukemia
te |
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PARP PolyADP ribose polmerase |
bition of DNA repair
- detects single strand breks and prevents repair inhi |
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olaparib |
PARP inhibitor |
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IFNa |
non specific immunomodulator - decrease proliferation by blocking some factors invloved and enhance imune stuff |
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sipuleucel - T |
vaccine custom to pts cancer (cytotix T cells involved) |
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prednisome |
glucocordicoid receptor agonist - regulates gene expression - can decrease some inflam genes (Il 1 and Il 2) increase anti inflam genes high doses can induce apoptosis |
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azathioprimne
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6 - mercaptopurine - blocks Dna and Rna synthesis |
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mycophenolate mofetil ( MMF) |
inhibits inosine monophosphate dehydrogenase - blocks de novo purine synthesis (T and B cell deendant) |
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methotrexate |
mimics folate - inhibits DHFR - targets proliferating cells |
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cyclosporine and acrolimus |
calcineurin inhibitors - inhibits transcripton factors in T cells - nuclear factor of activated T cells (NFAT) - good for organ transplants |
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sirolimus |
binds FKBP inhibits mTOR - blocks cell cycle progression from G1 to S |
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polyclonal antibodies |
agaisnt lymphocytes (ALG or ATG) prevent initial graft rejecton |
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romonab
mu |
OKT3 - reduces internalization and kills cytotox human t cells |
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daclizumab
c |
prevent activation of T cells prevent organ rejection |
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nfliximab
i |
antibody agaisnt tumor necrosis factor a - chrons and r arhritis |
