Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Side effects of rapid growth if on GH in kids
|
scoliosis slipped capital femoral epiphysis
|
|
|
Endocrine disorders caused by GH
|
Insulin resistance Hypothryroidism
|
|
|
Side effects of GH in adults
|
peripheral edema carpal tunnel syndrome myalgias and arthralgias
|
|
|
MOA of GH
|
GH from the pituitary hits GH receptor on the liver which causes the liver to produce IGF-1 which binds to IGFBP-3(which stabilizes the IGF-1)
|
|
|
Mecasermin
|
complex of IGF-1 and IGFBP-3
|
|
|
Mecasermin clinical use
|
servere primary IGF-1 deficiency
|
|
|
Octreotide, Lanreotide
|
Somatostatin analogues (inhibit GH release from pituitary)
|
|
|
Octreotide, Lanreotide clinical use
|
Acromegaly (adults) or gigantism (children), carcinoid syndrome, diarrhea from pancreatic VIPoma
|
|
|
Octreotide, Lanreotide MOA
|
binds to the somatostatin receptor on the pituitary adenoma and inhibits the release of GH (or on the neuroendocrine tumor of VIPoma and inhibits the release of GH)
|
|
|
Octreotide, Lanreotide adverse effects
|
biliary sludge and gallstones, hypo or hyperglycemia, hypothyroidism, nausea, vomiting, diarrhea, abdominal cramps, steatorrhea
|
|
|
Pegvisomant
|
GH receptor antagonist
|
|
|
Pegvisomant MOA
|
blocks the GH receptor on the liver so no IGF-1 is made
|
|
|
Pegvisomant clinical use
|
acromegaly
|
|
|
Bromocriptine, Cabergoline
|
Dopamine agonists that at high levels will also decrease GH release from the pituitary
|
|
|
Why does increased prolactin cause amenorrhea and infertility?
|
increased PRL leads to decreased GnRH which leads to decreased LH and FSH
|
|
|
How does dopamine agonists help treat the amenorrhea and infertility of hyperprolactin?
|
They decrease the PRL levels which leads to an increase in GnRH and an increase in LH and FSH
|
|
|
Bromocriptine, Cabergoline side effects
|
Nausea and Vomiting, headache postural hypotension, nasal congestion, digital vasospasm, CNS effects
|
|
|
Which dopamine agonist is preferred for pregnancy?
|
Bromocriptine
|
|
|
Which dopamine agonist has a longer half life and works better with fewer side effects?
|
Cabergoline
|
