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15 Cards in this Set
- Front
- Back
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Serotonin receptors that are targeted in treatment of migraines
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5-HT1B, 5-HT1D both are Gi and decrease cAMP
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Serotonin receptor that is a Na, K ion channel
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5-HT3
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Serotonin causes constriction of dilation of veins?
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venoconstriction
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Drugs classes for acute/abortive treatment of migraines
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5HT-1D/1B agonists (Triptans), Ergot alkaloids, and NSAIDS
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Sumatriptan, Naratriptans, -triptans
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used for migraines and given orally and some other routes, 1st line
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Triptans sied effects
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injection site reactions (sumatriptans), bitter taste (sumatriptan nasal spray), acute but small rise in blood pressure
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Triptans contraindication
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HTN, severe hepatic disease, renal disease, PVD, WPW syndrome
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Ergotamine, Dihyroergotamine
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ergot alkaloids for migraines
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Ergot Alkaloids side effects
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Black Box for peripheral ischemia, prolonged vasospasm which leads to gangrene in overdoses
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Ergot Alkaloids contraindications
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Pregnancy is most important
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Metoprolol, Propranolol, Timolol
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beta-blockers which take up to 3 months to see improvement
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Drugs for preventative/prophylactic treatment of migraines
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beta-blockers, antidepressants, anticonvulsants, and butterbur supplement
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Verapamil
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is often the 1st line prophylactic agent for migraines but there are conflicting reults as to the success
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Amitriptyline, Velafaxine
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antidepressants for migraines
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Valproate, Topiramate
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anticonvulsants for migraines, Valproate is contraindicated in pregnancy
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