Dopamine

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Trade name. generic name

Back 1

Dopamine, inotropin

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Classification

Back 2

Adrenergic agonist, inotrope, vasopresser

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MOA

Back 3

Stimulaters alpha and beta adrenergic recepters. At Moderate doses dopamine stimulates beta 1 recepters resulting in inotropy and increased cardiac output while maintaining dopamingeric induced vasodilatory effects.
At high doses alpha adrenergic agonism predominates and increased peripheral vascular resistance and vasoconstriction result.

Front 4

Indications

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Hypotension and decreased cardiac output associated with cardiogenic shock and septic shock, hypotension after return of spontaneous circulation flowing cardiac arrest, symptomatic bradycardia and unresponsibe to atropine.

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Contraindications

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Pheochromocytoma, VF,VT, or other ventricular arrhythmias known sensitivity, Correct any hypovolemia with volume fluid replacement before adminsteresting dopamine

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Side Effects

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Tachycardia, arrhythmias, skin necrosis, sever hypertension from excessive vasoconstriction, angina, dyspnea, headache and vomiting

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Cautions

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Half life 2 minutes
Pregnancy class c

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Dosage /Route of administration

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Adult: 2-20mcg/kg/min to desired effect. Cardiac dose is usally 5 to 10 mcg/kg/min. Vasopressor dose is usally 10 to 20 mcg/kg/min. Little benefit is gauned beyond 20 mcg/kg/min.