Dopamine

Front 1

Classification

Back 1

Direct and indirect acting sypatomimetic; cardiac stimulant and vasopressor, natural catacholamine, adrenergic agonist, inotrope

Front 2

Action

Back 2

Stimulates alpha and beta adrenergic receptors.

At moderate doses (2-10mcg), dopamine stimulates Beta1 receptors, resulting in inotropy and increased cardiac output while maintaining dopaminergic indices vasodialatory effects.

At High doses, (>10mcg/kg/min), alpha adrenergic agonism predominates, and increased peripheral vascular resistance and vasoconstricion result.

Front 3

Indications

Back 3

Hypotension and decreased cardiac output associated with cardiogenic shock and septic shock, hypotension after ROSC, symptomatic bradycardia unresponsive to atropine.

Front 4

Adverse Effects

Back 4

Tachycardia, arrythmias, skin and soft tissue necrosis, severe hypotension from excessive vasoconstriction, angina, dyspnea, headache, Nausea/vomiting.

Front 5

Contraindications

Back 5

Pheochromocytoma, VF, VT or other ventricular arrythmias, known sensitivity (including sulfites). Correct any hypovolemia with volume fluid replacement before administering dopamine.

Front 6

Dosage

Back 6

Adult and Pedi: 2-20mcg/kg/min IV, IO infusion.
Starting dose 5mcg/kg/min, may gradually increase by 5-10mcg/kg/min to desired effect.
Cardiac dose is usually 5-10mcg/kg/min
Vassopressor dose is usually 10-20mcg/kg/min

Half life 2 minutes