Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/25

Click to flip

25 Cards in this Set

  • Front
  • Back
DMARDS
Decrease immune response
Impede disease progression
May/may not be anti-inflammatory/analegsic
Slow acting (req. wks. to mon)
High incidence of toxicity.
METHOTREXATE:
`
- inhibits the production of cytokines such as TNF-a
- decrease production of PGS.
- Is a folate antimetabolite that inhibits dihydrofolate reductase.
Methotrexate SE:
- nausea
- stomatitis
- GI discomfort
- diarrhea
Methotrexate A.E.:
- hepatotoxicity progressing to cirrhosis.
- pneumonitis leading to pulmonary fibrosis.
- bone marrow depression.
Contraindication of Methotrexate:
1. tetratogenic compound.
2. liver, lung, kidney, immunodeficiency, blood dycrasias, hypersensitivity.
Drug Interactions w/ Methotrexate:
1. phenytoin
2. sulfonylurea
3. sulfonamides
Hydroxychloroquine (PLAQUENIL)
irreversible retinal damage.

OPTHALAMIC MONITORING REQUIRED PERIODICALLY.
LEFLUCOMIDE (Arava)
Action due to ACTIVE METABOLITE: formed in liver and plasma:

- inhibits dihyrdrorolate dehydrogenase (DHODH) (enzyme pyrimidine)
SE. Of LEFLUCOMIDE:
DIARRHEA.
ALOPECIA
ELEVATED LIVER ENZYMES
AZATHIOPRINE (IMURAN)
Purine metabolite
AZA converted to 6-MP
OT: 6-MP converted to additional metabolites inhibit DE NOVO PURINE SYNTHESIS.
MAJOR DRUG INTERACTION: ALLOPURINOL + AZATHIOPRINE
xanthine oxidase metabolizes 6-MP.
D-PENCILLAMINE (CUPRIMINE)
- A METABOLITE OF PENCILLIN
- chelating agent
D-Pencillamine (CUPRIMINE)
Side Effect:
1. Cutaneous Lesions
2. Hematological (leukopenia, thrombo, aplastic anemia)
3. Renal (proteinuria, hematuria)
Gold compounds:
IM PREPARATIONS:
Gold Na thiomalate
(MYOCHRYSINE)
Excreted: renally, better absorbed.

SE: NITROID REACTION (flushing, weakness, nausea, dizziness)
Gold compounds:
Oral Preparations:
Auranofin (Riduara)
Better tolerated
Excreted: Feces
SE: GI disturbances
Gold Preparation:
Progress of the disease and to induce remission
ADVERSE EFFECT:
SKIN AND MUCOUS MEMBRANE.
Gold Preparation Toxic Effects:
KIDNEY: Proteinuria, Albuminuria, hematuria.
BLOOD: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.
Contraindications auranofin:
Auranofin should NOT be administered after the occurrences of pulmonary fibrosis, necrotizing enterocolitis, & exfoliative dermatitis.
Infliximab (REMICADE)
monoclonal antibody that binds to and neutralizes the activity of TNF-a.
- s.e: upper respiratory tract infection, TB
Etanercept (ENBREL)
- recombinant fusion protein containing two soluble TNF p75 receptr moieties linked to the Fx portion of human IgG.
Adalimumab (HUMIRA)
recombinant anti-TNF monoclonal antibody
Common Adverse Effect of Anakinra (KINERET)
A.REACTIONS AT INJ. REACTIONS (redness, bruising, pain, and inflammation)
Anakinra (KINERET)
IL-1 antagonist, acts by blocking the action of IL-1
- decreasing the pain and inflammation produced by IL-1.
Abatacept (ORENCIA)
- solube fusion protein CTLA-4
- T CELL NOT ACTIVATED
ADVERSE EFFECT OF abatacept (orencia)
Nasopharyngitis, URI
CAUTION: COPD