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10 Cards in this Set

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  • Back
How are the "typical" or traditional antipsychotics different from the "atypical" or novel antipsychotics?
Older, typical antipsychotics are more effective in treating positive symptoms of psychosis. The atypical drugs are effective in treating both the positive and negative symptoms of psychosis.
What is one way to identify an antipsychotic drug?
the ending "azine"
What are the names of some of the new atypical antipsychotics?
Clozapine (Clozaril)
Risperidone (Risperdal)
Olanzapine (Zyprexa)
Quentiapine (Serequel)
Ziprasidone (Geodon)
What are the names of some of the older typical antipsychotics?
Halperidol (Haldol)
Thioridazine (Mellaril)
Prolixin, Navane, Stelazine
What are the positive symptoms of psychosis?
hallucinations, delusions, disorganized thinking
What are the negative symptoms of psychosis?
Affective flattening, lack of motivation, poverty of speech.
What is mean by the term "depot neuroleptics"?
Antipsychotics administered intramuscularly (by injection). Doses last 2-4 weeks. If the word "decanoate" is added after the name of an antipsychotic, it means that it is to be administered in the depot form. These would typically be Prolixin and Haldol.
What is the presumed mechanism of action in antipsychotics?
Antipsychoitcs are dopamine antagonists, meaning that the lower the levels of dopamine in the brain by blocking postsynaptic dopamine receptors. "Dopamine hypothesis" - schizophrenia results from excessive dopamine - however, not fully confirmed. Novel or atypical antipsychotics exert stronger effects on sertoini, anticholinergice, antihistaminergic that just dopamine.
What factors are correlated with better outcome of treatment for schizophrenia with antipsychotics?
Later age of onset,
acute onset,
good premorbid functioning,
anxiety or other affective symptoms (as opposed to emotional blunting)
systematized and focused delusions
precipitating factors, married status,
family history of affective disorders
no family history of schizophrenia.
What are the drugs of choice for dementia?
Non-antipsychotic, such as Aricept may temporarily reverse the cognitive decline associated with DAT