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5 Cards in this Set
- Front
- Back
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Thiazides:
Drugs (order of duration), MOA,Urine conc, CU, AR |
Hydrochlorathiazide--> Chlorthiazide--> Chlorthalidone
MOA: block Na/Cl symporter in DCT Urine: low Ca, uric acid, HCO3 CU: chronic HTN, nephrogenic DI, edema, pregnancy AR: hypokalemia, hyperglycemia, increased LDL at high conc, Li tox, pancreatitis, hyperuricemia, hypochloremic metabolic ALKALOSIS, impotence |
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Loop Diuretics:
Drugs (names), MOA, urine conc, CU, AR |
drugs: furosemide (most popular), ethycrinic acid (not sulfa), bemetanide
MOA: inh Na/K/2Cl symporter Urine conc: increases Ca, decrease uric acid CU: DOC for CHF, acute HTN, edema, ascites,acute pulmonary edema, acute hypercalcemia (sarcoidosis/malignancy) AR: ototoxcity (more with ethycrynic acid), hypokalemia, hypocalcemia, hypokalemic metabolic alkalosis, hyperuricemia |
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K sparing Diuretics:
Drugs (names), MOA, urine conc, CU, AR |
drugs: spirinolactone, canrenone, triamterene, amiloride
MOA: S/C--> inh aldosterone, T/A--> block epithelial Na channels Urine--> inc Na, dec K, inc H CU--> treat digoxin tox, primary aldosteronism AR--> hyperkalemia,hyperkalemic metabolic acidosis S--> gynecomastia and alopecia, A--> HS rxn |
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Mannitol:
MOA, CU, AR |
MOA: decrease ICV due to osmalility
CU: increased ICP, glaucoma, solute overload (rhabdo/hemolysis) AR: contraindicated for CHF, headache, vomiting, nausea |
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Acetozolamide:
MOA, CU, AR |
MOA: inh carbonic anhydrase, causes inc in Na absorption and K secretion and results in HCO3 secretion
CU: glaucoma, acute mountain sickness, edema AR: metabolic acidosis, cross allergenicity, hypokalemia |
