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18 Cards in this Set
- Front
- Back
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Carbonic Anhydrase Inhibitor
Example
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Acetazolamide |
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Carbonic Anhydrase Inhibitor
Action & Effect |
Inhibits CA = Inhibits dehydration of H2CO3 and hydration of CO2 =
impaired NAHCO3 & H2O reabs = diuresis |
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Carbonic Anhydrase Inhibitor
Site of Action |
Early Proximal Tubule |
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Carbonic Anhydrase Inhibitor Strength of Effect |
Modest because does not affect NaCl reabs |
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Loop Diuretics Example |
Furosimide (Lasix) |
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Loop Diuretics Action & effect |
Inhibit NKCC2 co-transporter = inhibits NaCl reabsorption
= naturesis + diuresis |
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Loop Diuretics Site of Action |
Thick Ascending Limb of Loop of Henle |
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Loop Diuretics Strength of Effect |
Extremely potent; use for edema and rapid diuresis |
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Thiazides Examples |
Cholorothiazide
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Thiazide Action & Effect |
Inhibit NCC co-transporter; mild naturesis + diuresis |
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Thiazides Site of Action |
Early Distal Tubule |
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Thiazides Strength of Effect |
Mild, but enough to treat HTN |
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Potassium Sparing Diuretics Examples (2) |
Amiloride Spironolactone |
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K+ Sparing Diuretics - Amiloride Action & effect |
Block ENaC = inhibit Na Reabs. = collapse Vte (-) = inhibit K+ secretion;
effect - mild naturesis |
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K+ Sparing Diuretics - Amiloride Site of Action |
Late Distal Tubule |
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K+ Sparing Diuretics - Amiloride Strength of effect |
Mild |
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K+ Sparing Diuretics - Spironolactone Action & effect |
Competes with aldosterone for mineral corticoid receptors (MR) = prevents ENaC production = dec. ENac = inhibited Na reabsorption
effect = naturesis |
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K+ Sparing Diuretics - Spironolactone Site of Action |
Late distal tubule + Cortical Collecting Duct |
