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52 Cards in this Set
- Front
- Back
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Which diuretics are given orally for the tx of essential hypertension
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thiazide diuretics
k sparring w/ thiazide |
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Thiazide diuretics work synergistic with what ?other diuretic (when pts are refractory to diuretic therapy)
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Loop
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Which diuretic works to mobilize edema fluid assoc. with renal, hepatic, or cardiac dysfunction
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thiazde and loop
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Thiazide diuretics tx:
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essential htn
diabetes Insp. hypercalcemia |
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Name some Thiazide diuretic drugs:
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Chlorothiazide
chlorthalidone hydrochlorothiazide hydrodiuril Indapamide methclothiazide Metolazone |
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MoA of thiazide
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Inhibits reabsorption of na and cl ions,in the corical portions of the loop ascending portion of the loop of henle, and proximal renal tubules and distal renal tubules
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Which diuretic is a weak diuretic and is tx for glaucoma and met.alkalosis
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Carbonic anhydrse inhibitors
acetazolamide (sulfa drug that binds to Carbonic anhydrase) |
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Which diuretic is aldosterone antagonist
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Spironalactone(aldosterone antagonist)
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Which diuretics decrease ICP and IOP
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osmotic, loop, carbonic anhydrase inhibitors (acetazolamide)
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Which diurtics is for tx of ARF, heart failure, pulm edema
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loop
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Which diurtic potetiates NMB
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loop
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Which diurtetic could cause deafness
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loop
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Which diuretic increases osmolarity of renal tubular fluid and prevents H20 reabsorption
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osmotic
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Which diuretic excrete Na, cl,k, mg, bicarb
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thiazide
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Which diuretics decrease bicarb
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thiazide, Carbonic anhydrase inhibitors, osmotic, k-sparring
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Which two diuretics increase glucose
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thiazide, loop
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What do thiazide diurtics do to C.O
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decrease, due to decreased BP and decreased extacellular fl. vol
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Thiazide diuretics do what to peripheri
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vasodilation
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adverse effects of thiazides when given chronically for ess. htn
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hypokalemia
hypochloremia met alkalosis |
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side effects of hypokalemia
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cardiac arrhythmias
skeletal muscle weakness ileus nephropathy increase dig tox potentiation of NMB |
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Signs of hypovolemia
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ortho hypotension
increased Hct and Bun |
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Increases BSugar
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Thiazide and loop
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increase gout
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thaiazide (increases uric acid)
and loop |
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What type of diuretic is mannitol
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osmotic
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What drugs are osmotic diuretics
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mannitol and urea
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What diuretics are:
-Resist metabolism -pharmacologically inert -Undergo limited reabsorption from renal tubules -freely filtered by glomerulus |
Osmotic diuretic
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which diuretic is used for:
prophylaxis agains ARF diff. diag. of acute oliguria tx of incr. ICP decreas IOP |
Mannitol
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Principle side effect of Potassium sparring diuretics
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high K
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Which diuretic retains cloride
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Carbonic anhydrase Inhibitor
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Which diuretic retains K
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k sparring,and aldosterone antagonist
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What ions does osmotic diuretics excrete
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H2O, na, cl, hco3
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What ions does aldosterone antagonist excrete
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na, h2o
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Which diuretic blocks the effects of aldosterone
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aldosterone antagonist
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Which diuretic Inhibits the reabsorption of Na and cl
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loop, thiazide
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Which diuretics directly works on renal tubular tansport mechanisms in distal convoluted tuble independent of aldosterone
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k sparing
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Which diuretic do you have to watch for meab. alkalosis
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thiazide
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Which drugs decrease CSF
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carbonic anhydrase Inhib.
Loop Osmotic |
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Which diuretic is a sythetic steroid
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Spironalactone (ald.antag)
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Which decreases seizure activity
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acetazolamide
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Which is used for alttitud sickness
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acetazolamide
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Which diuretic has no effective as antihypertensive
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loop
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How does loop tx pulm edema
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peripheral vasodilation after diuresis causes decreased veouns return, decreased preload
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Which drug in nephrotoxic with aminoglycodides
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loop
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Which diuretic does not work if GFR is <20-30
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thiazide
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Which diuretic works despite GFR
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Loop
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Which has an adv effect of allergic interstital nephritis
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loop
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Which drug can cause Lithium toxicity
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loop
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Which drugs are completely filtered by glomeruli
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mannitol (osmotic)
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Pt can become tolerant to
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mannitol
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Which drug draws fluid from ICS to ECS
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Osmotic
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Which diuretic should u use for heart failure instead of osmotic
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loop
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Which diuretic for prophalaxis of ARF ( CABG, trauma..)
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Osmotic
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