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13 Cards in this Set
- Front
- Back
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Inhibitors of Carbonic anhydrase
1o site of action? |
PROXIMAL tubule
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Osmotic diuretics
1o site of action? |
Loop of Henle
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Inhibitors of Na+-K+-2Cl- symport
1o site of action? |
Thick ascending limb
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Inhibitors of Na+-Cl- symport
1o site of action? |
Distal convoluted tubule
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Inhibitors of renal epithelial sodium
1o site of action? |
Late distal tubule and collecting duct
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Antagonists of mineralocorticoid receptors
1o site of action? |
Late distal tubule and collecting duct
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INHIBITORS OF CARBONIC ANHYDRASE
Prototype? |
Acetazolamide
Others: Dichlorphenamide, Methazolamide |
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INHIBITORS OF CARBONIC ANHYDRASE
MOA |
inhibit both membrane-bound and cytoplasmic forms of carbonic anhydrase nearly complete abolition of NaHCO3 reabsorption in proximal tubule
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INHIBITORS OF CARBONIC ANHYDRASE
2ndary site of action: |
collecting duct system----inhibition of secretion of titratable acid
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INHIBITORS OF CARBONIC ANHYDRASE
Toxicity, Adverse Effects, Contraindications, Drug Interactions |
-BM depression
-Skin toxicity -Sulfonamide-like renal lesions -Allergic reactions in pts allergic to Sulfonamides -Most reactions due to metabolic acidosis Diversion of ammonia from urine into systemic circulation – contraIx in w/ hepatic cirrhosis |
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INHIBITORS OF Na+-Cl- SYMPORT(THIAZIDE AND THIAZIDE-LIKE DIURETICS)
attenuate the diuretic response |
Probenecid
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INHIBITORS OF Na+-Cl- SYMPORT(THIAZIDE AND THIAZIDE-LIKE DIURETICS)
Effect on RBF? GFR?Na and Cl excretion? |
RBF: none
GFR: variable reduction Na and Cl excretion: Increased |
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INHIBITORS OF Na+-Cl- SYMPORT(THIAZIDE AND THIAZIDE-LIKE DIURETICS)
Toxicity, Adverse Effects, ContraIx CNS? GIT? Hematological? Dermatological? Sexual?Glucose tolerance? Pregnancy? |
CNS – vertigo, HA, paresthesias, xanthopsia and weakness
-GIT – anorexia, N&V, cramping, diarrhea, constipation, cholecystitis, pancreatitis -Hematological-blood dyscrasias -Dermatological-photosensitivity, skin rashes -Erectile dysfunction -Decreased glucose tolerance -Risk of transient volume depletion resuting in placental hypoperfusion |
