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50 Cards in this Set
- Front
- Back
fetal placental struture that secretes hCG
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syncitiotrophoblast
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maternal component of placenta
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decidua basalis
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order these molecules by how much energy they contain that an be made available to fuel endergonic reactions?
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glucose> pyruvate> ATP> AMP> adenosine
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what are the stages of an embryo between conception and an inner ell mass
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zygote-> morula-> blastocyst-> inner cell mass and trophoblast
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patient with aganglionic colon and other neural crest derivative deficiencies. What other problems would she have?
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spiral septum, albinism, dental anomalies, PNS, bones of the skull, hearing problems, vision problems, thyroid problems, heart problems, adrenal gland
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list some drugs contraindicated in pregnancy
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ACEIs, alkylating agents, carbamazepine, valproate, lithium ,warfarin, thalidomide, phenytoin, tetracyclines, folate antagonists, DES, AG's, sulfa, FQ, MTX, pyrimethine
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when does organogenesis take place?
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3-8
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what is the relationship between the notochord, the neural plate, the neural tube, and the neural crest cells
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notochord forms neural plate, neural tube and neural crest arise from the neural plate
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embryonic origin: anterior pituitary
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surface ectoderm
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embryonic origin: cornea
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neural crest
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embryonic origin: lens
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surface ectoderm
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embryonic origin: retina
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neural crest
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embryonic origin: olfactory epithelium
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surface ectoderm
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embryonic origin: mammary glands
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surface ectoderm
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embryonic origin: salivary glands
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surface ectoderm
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embryonic origin: sweat glands
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surface ectoderm
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embryonic origin: tissue just above and below the pectinate line
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endoerm; surface ectoderm
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teratogenesis of ACE inhibitors
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kidney failure
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teratogenesis of aminoglycosides
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otoxicity
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teratogenesis of diethylstilbestrol
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clear cell vaginal CA
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teratogenesis of tetracyclines
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teeth discoloration
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teratogenesis of valproic acid
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neural tube defects
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which vitamin should not supplemented in large amounts during pregnancy? why?
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Vitamin A- prevents neural crest migration, HOX gene expression is altered
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what molecules provide the structural framework for DNA and the nuclear envelope
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nuclear lamins
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what must be present on a protein in order for that protein to gain entry in to the nucleus
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nuclear localization signal
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which types of proteins are responsible for fostering the progression through the cell cycle
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cyclins and CDK's
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which cyclin-CKD complexes assist in the transition from G1 to S?
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cyclin D- CDK 4
cyclin E- CDK 2 |
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which tumor suppressor proteins prevent progression into S phase?
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p53, Rb
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which cyclin-CDK complexes assist in the progression from G2 to M phase
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cyclin A- CDK 2
cyclin B- CDK 1 |
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what molecule targets proteins in the ER for lysosomes?
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mannos-6-phosphate
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what is deficient in I-cell disease
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ability to phosphorylate mannose to mannose-6-phosphate to mark proteins for lysomal degradation
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what are the different methods of proteolysis?
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proteasomes
lysosomes calcium-dependent enzymes (extra-lysosomal) |
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which types of cells have lots of smooth ER?
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adrenal cortex
hepatocytes |
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which amino acids are in nuclear localization signals?
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lysine
proline arginine |
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what is the most common cause of mental retardation in infants?
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FAS
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how do Rb protein and p53 regulate the cell cycle?
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stop S phase from starting
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what drugs act on microtubules?
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vincristine/vinblastine
griseofulvin paclitaxel -bendazoles -colchicine |
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what two fundamental substances are required to make most things work inside the cell?
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ATP and calcium
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which organelle is responsible for the breakdown of very long-chain fatty acids?
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peroxisome
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intermediate filament in connective tissue
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vimentin
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intermediate filament in muscle
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desmin
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intermediate filament in epithelial tissue
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cytokeritin
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intermediate filament in axons
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neurofilaments
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defects in kartagener's syndrome
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primary immotile cilia
dynein arm defect bronchiectasis- sinusitis infertility associated with situs inversus |
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arachadonic acid product that causes increased bronnchial tone
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LTC4, LTD4, TXA2
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arachadonic acid product that causes decreased bronchial tone
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PGE2, PGF2, PGI2
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arachadonic acid product that causes increased platelet aggregation
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TXA2
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arachadonic acid product that causes decreased platelet aggregation
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PGI2
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arachadonic acid product that causes increased uterine tone
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PGE2, PGF2a
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arachadonic acid product that causes decreased uterine tone
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PGI2
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