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21 Cards in this Set

  • Front
  • Back
3 components of hemostasis
blood vessel wall
platelets
coagulation factors
endothelium antagonize formation of clots by:
-negative surface charge (repel plts)
-expression of endogenous anticoagulants (heparin)
-production of substances that are vasodilatory and interfere with plt activation (ADPases)
Constant laminar flow:
minimizes vascular trauma and dilutes any local accumulation of procoagulats
Edothelin is a
vasoconstrictor that temporarily decreases bld flow.
Primary hemostatic plug forms when
injury to endothelial extracellular matrix which results in plt adhesion and activation
The primary hemostatic plug ultimitaly: (falls off or remains attached)
Which type of hemostatic plug falls off (primary or secondary)
Tissue factor
triggers sequential activatoin of a cascade of protein coagulation that eventually forms a thrombin.
Thrombin converts ____ to ___.
What converts fibrinogen to fibrin?
Secondary hemostatic plug is formed by:
fibrin which polymerizes and incorprates platelets forms the ___ ____ ___.
What is activated at the same time as clotting?
Counter-regulartory anticoagulant mechanisms to contain the process to the site of the injury.
Overactivity of coagulation leads to:
Thrombosis
Underactivity of coagulation leads to:
Uncontrolled hemorrage
___ produces NO (nitric oxide)
Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.
___ produces protacyclin
Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.
___ produces ADP (degrades a stimulant of platelet aggregation)
Endothelial cells produce ___ an antithrombin which degrades a stimulant of plt aggregation.
___ produces membrane associated heparin-like anticoagulats (cofactors for antithrombin III which inactivates coagulation factors.
Endothelial cells produce ___ an antithrombin which inactivates coagulation factors
___ produces proteins C and S (degrade coagulation factors)
Endothelial cells produce ___ an antithrombin which are vitamin K dependant factors that degrade coagulation factors.
___ produces tissue plasminogen activator (t-PA) that promotes lysis of fibrin - dissolve clots
Endothelial cells produce ___ an antithrombin which promote lysis of fibrin (dissolve blood clots).
___ produces vWF (von Willebrand factor
Endothelial cells produce ___ a prothrombin which needed for platelets to bind to collagen and other surfaces.
___ produces tissue factor
Endothelial cells produce ___ a prothrombin which activates teh coagulation cascade.
___ produces inhibitors of plasminogen activator (PAIs)
Endothelial cells produce ___ a prothrombin that inhibits the lysis of fibrin.