Dist Of Circ

Front 1

3 components of hemostasis

Back 1

blood vessel wall
platelets
coagulation factors

Front 2

endothelium antagonize formation of clots by:

Back 2

-negative surface charge (repel plts)
-expression of endogenous anticoagulants (heparin)
-production of substances that are vasodilatory and interfere with plt activation (ADPases)

Front 3

Constant laminar flow:

Back 3

minimizes vascular trauma and dilutes any local accumulation of procoagulats

Front 4

Edothelin is a

Back 4

vasoconstrictor that temporarily decreases bld flow.

Front 5

Primary hemostatic plug forms when

Back 5

injury to endothelial extracellular matrix which results in plt adhesion and activation

Front 6

The primary hemostatic plug ultimitaly: (falls off or remains attached)

Back 6

Which type of hemostatic plug falls off (primary or secondary)

Front 7

Tissue factor

Back 7

triggers sequential activatoin of a cascade of protein coagulation that eventually forms a thrombin.

Front 8

Thrombin converts ____ to ___.

Back 8

What converts fibrinogen to fibrin?

Front 9

Secondary hemostatic plug is formed by:

Back 9

fibrin which polymerizes and incorprates platelets forms the ___ ____ ___.

Front 10

What is activated at the same time as clotting?

Back 10

Counter-regulartory anticoagulant mechanisms to contain the process to the site of the injury.

Front 11

Overactivity of coagulation leads to:

Back 11

Thrombosis

Front 12

Underactivity of coagulation leads to:

Back 12

Uncontrolled hemorrage

Front 13

___ produces NO (nitric oxide)

Back 13

Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.

Front 14

___ produces protacyclin

Back 14

Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.

Front 15

___ produces ADP (degrades a stimulant of platelet aggregation)

Back 15

Endothelial cells produce ___ an antithrombin which degrades a stimulant of plt aggregation.

Front 16

___ produces membrane associated heparin-like anticoagulats (cofactors for antithrombin III which inactivates coagulation factors.

Back 16

Endothelial cells produce ___ an antithrombin which inactivates coagulation factors

Front 17

___ produces proteins C and S (degrade coagulation factors)

Back 17

Endothelial cells produce ___ an antithrombin which are vitamin K dependant factors that degrade coagulation factors.

Front 18

___ produces tissue plasminogen activator (t-PA) that promotes lysis of fibrin - dissolve clots

Back 18

Endothelial cells produce ___ an antithrombin which promote lysis of fibrin (dissolve blood clots).

Front 19

___ produces vWF (von Willebrand factor

Back 19

Endothelial cells produce ___ a prothrombin which needed for platelets to bind to collagen and other surfaces.

Front 20

___ produces tissue factor

Back 20

Endothelial cells produce ___ a prothrombin which activates teh coagulation cascade.

Front 21

___ produces inhibitors of plasminogen activator (PAIs)

Back 21

Endothelial cells produce ___ a prothrombin that inhibits the lysis of fibrin.