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6 Cards in this Set
- Front
- Back
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what does the granulosa cell make?
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estrogen and inhibin in response to FSH
Sertoli cell makes activins and inhibin in response to FSH |
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LH stimulates which female cell?
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theca cell
to make androstenedione --> transported to granulosa cell, where it is made into estrogen upon stimulation by FSH |
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FSH stimulates what in female?
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follicles in the ovary and production of estrogen by granulosa cells
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causes of primary amenorrhea
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1) pregnancy
2) hypothalamus / pituitary -Kallmann's, KAL(X-link), FGFS1, neurokinins, leptin, GnRH mut, GnRH receptor mut, FSH, LH mutation 3) ovarian: fibrotic organization of ovary -turner's 1:2000-5000, mosaics can develop webbed neck, genu valgum, low hairline, madelung deformity, knuckle knuckle dimple knucke, coarctation of aorta, hashimotos, alopecia, vitiligo -46XXstreak gonad -46XY Swyer syndrome - lack of testis determining factor 4) anatomic -outflow tract or uterus 5) receptor / enzymatic defect -17OHase def -3b OH def |
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evaluation of amneorrhea
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absent breast - FSH up = gonadal dysgenesis: karyotype next
uterus asent, FSH nl -- muellerian agenesis or AIS FSH inappropratly nl or low -- work up of pituitary/hypothalamic amenorrhea |
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secondary amenorrhea
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functional (anorexia, stress)
infiltrating lesions -lymphoma, langerhans cell histiocytosis, sarcoidosis, craiopharung, mets, .... -hypothyoid |
