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3 Cards in this Set
- Front
- Back
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How do CD8+ T-cells (cytotoxic lymphocytes) influence transplant rejection?
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Mature CD8+ CTLs lyse grafted tissue.
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How do CD4+ helper T-cells influence transplant rejection?
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CD4+ helper T-cells recognize antigens presented by donor dendritic cells, proliferate, and secrete cytokines that increase vascular permeability and draw lymphocytes and macrophages to the grafted tissue.
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What type of cells in the donor tissue are the most important antigens for intiating a rejection response?
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Donor dendritic cells
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