Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/65

Click to flip

65 Cards in this Set

  • Front
  • Back
toxicity IV arrhyth
constipation, flushing, edema, CV (CHF, AV block, sinus node depression)
IC arrhyth
flecainide, ecainide, propafenone
prop/use IC
no affect AP, useful in VT that ->VF or intractable SVT. (Concern safety-last resort refractory arrhyth)
mech sulfonylureas
stimulate ins release, closes K channel on beta-cell membrane incr Ca influx
general class I anti arrhyth:
Rx also used as?
affect which phase? esp in which cells?
affect conduction? threshold?
local anesthetics, decr conduction, (esp in depolarized). decr slope 4 and incr threshold for ABNL
STATE dependent
toxicity of inhaled anesthetics
halothane=hepatic
methoxyflurane=kidney
enflurane=sz
malignant hyperthermia (rare)
class IA arrhytmics
quinidine, amiodarone, procainamide, disopyramide
opoiod analges R
act at opoiod receptors
mu=morphine
delta=enkaphilin
kappa=dynorphin
drugs that decr slope ph 4
class I, II, IV arrhyth
toxicity amiodarone
pul fibrosis, hepatotoxic, change thyroid, also corneal deposit, photodermatitis, neuro, constipation, CVS
prop IB arrhyth
AP?
phase?
acts on which cells?
depol?
conduction?
refractory?
decr AP by decr phase 3, affect ischaemia or depolarized Purknje and ventricular
no change in depol, conduction or ERP
prop of III arrhyth
AP? ERP? QT?
when use?
incr AP duration by delay repol, incr ERP, incr QT. used when others FAIL
name III arrhyth
sotalol, ibutilide, bretylium, amiodarone, dofetilide "K IS BAD"
SE glitazone
weight gain, hepatotoxic (troglitazone)
toxicity quinidine
Cinchonism: HA, tinnitus, thrombocytopenia, torsades de pointes
which incr QT
IA, III
IB used for
acute ventricular (esp s/p MI) and digitalis-induced
Diphenoxylate
opoiod used for diarrhea
prop IV arrhyth
conduction? ERP? intervalchange? targets?
when used?
mostly affect AV node, decr conduction, incr ERP, incr PR, used in prevention nodal arrhythmias
Mg use in arrhyth
t de pointes, digoxin toxicity
mech II arrhyth
pathophysio of mech?
phase? in which cells?
interval change?
decr cAMP, decr Ca, suppress ABNL by decr slope ph 4. AV node esp sensitive, increase PR interval
prop of IA arrhyth:
AP, ERP, QT,
affect atria or ventricle?
increase AP, incr ERP, incr QT, effect both atrial and ventricle
how II arrhyth affect intervals
incr PR (as do class IV)
which particularly slow AV node
class II and IV
which agent doesn't slow conduction, not useful in atrial or AV arrhytn
lidocaine (IB)
what acts by suppressing arrhyth by increasing normal automaticity
quinidine
little effect on depol, decr repol
IB (decr AP)
doesn't affect ph 4, but decr threshold potl
flecainide (IC)
should not be used in CHF
(-) ionotropes: Flecainide, b blockers (II), disopyramide (IA), IV
name qualities IA (AP, conduction ERP)
longer AP, slow conduction, incr ERP, incr QT
often used maintain SR s/p DC
quinidine
in normal pts cause tachycardia
quinidine (anti Chol), also disopyr
arrhyth w 2 effect of peripheral vasoconstriction
disopyr
drug interaction w quinidine
-quinidine increases dig by displace
stimulate metab: phenytoin, rifampin,barbituates
inhibit: cimetidine
use in A flutter, A fib, AVNRT
II
act at delayed rectifier
sotalol
must be given IV
bretylium, lidocaine
adjust LF
lidocaine (also 1st pass liver)
IB mostly used for which type arrhyth
ventric
change in RF
procainamide, bretylium
good for rapid arrhyth
IB, IV (use dependent)
SE pulmonary fibrosis
tocainaide
affects atria>>ventricle
IV
t1/2 of weeks
amiodorane
how tx digoxin arrhyth
lidocaine or penytoin
properties lidocaine
decr ph 3, suppresses abnormal auto, doesn't slow conduction (not useful atrial or AV)
USE v arrhyth 2/2 MI
refractory ventr arrhyth
felcainide (IC)
entire class can induce arrhyth
III
risk T de pointes
quinidine, sotalol, ibutilide
use amiodarone
severe refractory SVT, VT due to toxic SE
agents refractory ventr
IC, III (Flecainide, Bretylium, Amiodarone)
control VR in a fib/flutter
digoxin, IV,
DOC a fib
propanolol (+/- anticoag)
DOC a flutter
propanolol or verapamil
DOC AVNRT
propanolol, verapamil (slow AV node conduction)
DOC SVT
adenosine
DOC V fib not responding to DC
epinephrine
DOC acute v tach
lidocaine
(lipp) qualities IB
when use?
binding prop?
depol? AP?
targets?
use vent arrhythmias, rapidly bind, little effect on depol, decr AP by decr repol, effect ischaemic
(lipp) qualities II
which phase? conduction? auto? other?
decr ph 4, decr auto, slow AV conduction, decr HR and contractility
lipp qualities III
AP? ERP? rest mem potl? cxn?
prolong AP no change resting mem potl, incr ERP QT, all can induce arrhyth
lipp qual IV:
phase? conduction? targets?
decr ph4, slow conduction esp AV node
qualities dig
increase ERP, slow conduction in Purkinje, decr ERP in atrial/vent
qualities adenosine
decr conduction, incr ERP, decr auto in AVN
antiarrhyth of phenytoin
improve AV conduction, useful in v arrhythm and esp dig toxicity