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5 Cards in this Set
- Front
- Back
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What kind of process is Diastology?
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Diastolic function is an active, energy dependent process
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What happens in Systole? (on a chemical intracellular level?)
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Systole-
influx of Ca++ ions binding to Troponin-C, allowing actin and myosin interaction |
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What happens in Diastole? (on a chemical intracellular level?)
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Diastole-
Removal of Ca++ions from Troponin-C by enzyme SERCA₂ inhibiting actin and myocin interaction |
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What is Diastolic Dysfunction?
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Failure of SERCA₂ reuptake of Ca++:
Slowing of myocardial relaxation Calcium levels do not return to normal diastolic levels Diastolic Ca++ overload Excessive diastolic tension and stiffness |
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What are some clinical S/Sx of Diast Dysfxn?
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DOE, Orthopnea, Crackles, Paroxysmal Nocturnal Dyspnea, Displaced Apical pulse, S3 & S4 extra heart sounds, JVD
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