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5 Cards in this Set

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  • Back
What kind of process is Diastology?
Diastolic function is an active, energy dependent process
What happens in Systole? (on a chemical intracellular level?)
Systole-
influx of Ca++ ions binding to Troponin-C, allowing actin and myosin interaction
What happens in Diastole? (on a chemical intracellular level?)
Diastole-
Removal of Ca++ions from Troponin-C by enzyme SERCA₂ inhibiting actin and myocin interaction
What is Diastolic Dysfunction?
Failure of SERCA₂ reuptake of Ca++:
Slowing of myocardial relaxation
Calcium levels do not return to normal diastolic levels
Diastolic Ca++ overload
Excessive diastolic tension and stiffness
What are some clinical S/Sx of Diast Dysfxn?
DOE, Orthopnea, Crackles, Paroxysmal Nocturnal Dyspnea, Displaced Apical pulse, S3 & S4 extra heart sounds, JVD