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15 Cards in this Set

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  • Back
  • 3rd side (hint)
What are the 5 classes of drugs used for DM?
Insulin, sulfonylureas, meglitinides, alpha-glucosidase
inhibitors, thiazolidinediones
Indian Sikhs Make Anti-Gujarat Inhibition Tricky
What do alpha-cells of the pancreas secrete?
How does glucagon work?
by increasing hepatic glucose output, it increases glucose concentration
What do beta-cells of the pancreas secrete?
How does insulin work?
lowers plasma glucose concentration by promoting uptake, utilization, and storage of glucose
What are some other names for DM I?
IDDM, insulin dependent, and juvenile-onset DM
What are some other names for DM II?
NIDDM, non-insulin dependent, and adult-onset DM
What is the mechanism behind DM I?
a deficiency of insulin that results from autoimmune destruction of pancreatic beta-cells
What is the mechanism behind DM II?
lipocytes and myocytes become less sensitive to insulin action or the pancreas produces less insulin
What are the 4 goals of DM treatment?
reduction in Hyperglycemia symptoms, Reduce/Delay onset/progression of Ocular, Renal, Hepatic, Cardiac, and Nervous Complications, improve and increase Quality of life, and Minimize Hypoglycemia
Reactive Hyperactive Sheiks Reduce and Delay Organization, Revolution, Hyperbole, Candor, and Networking Coldly, Insuring Qatar Maintains Hegemony
Why property of insulin makes it so it can't be taken PO?
It's a peptide (polar) hormone
Why does circulating insulin have such a short half-life?
Due to rapid removal by the liver and kidneys
When is insulin replacement therapy indicated?
Always for Type I, sometimes for Type II, and always for Gestational
What are the indications for insulin replacement in DM II?
Pts who can't control their condition with diet, exercise, and PO meds, and those with newly Dx DM II with severe, symptomatic hyperglycemia
What determines the rate of release insulin preparations?
The ratio of zinc