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10 Cards in this Set
- Front
- Back
What are the biguanines and teir MOA:
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Metformin; (GLucophage, Glucophage XR and Fortamet)
1. Decrease hepatic glucose production 2. Reduce intestinal glucose Absorption 3. Increase insulin sensitivity Basal |
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What are the side effects of Biguanines:
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Metformin side effects are
1. Diarhea, 2. Lactic acidocis |
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When is Metformin contraindicated?
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sCr 1.5 for males and sCr 1.4 for females.
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What are the usual doses of metformin?
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SD: 500 MD 2500 daily
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Which medications are weight neutral?
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Metformin, sitagliptin and saxagliptin (DPP-4 inhibitors)
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Glipizide, glyburide and glymeperide are all:__________. They work by __________and must be taken_______. Their main sidfe effects are_________
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Sulfonyl urea
Stimulating insulin secretion Basaly Hypoglucemia and weight gain |
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The best SU in renal insuficiency is _______. Hupoglycemia is more potenciated with this SFU__________
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Glypizide (SD 5mg MD 40 mg)
GLyburide ( SD 2.5-5 mg MD 20 mg) |
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Meglitanides include________and Repaglinide. They are similar to______however they work _________
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Nateglinide and Repaglinide.
Similar to sulfonyl urea mechanistically, they work faster |
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The side effects of Meglitanides are _______. They inhibit_____________
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Hypoglycemia and weight gain.
They inhibit ATP sensitive potassium channels. |
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Nateglinide and repaglinide must be taken at
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meal time.
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