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10 Cards in this Set

  • Front
  • Back
What are the biguanines and teir MOA:
Metformin; (GLucophage, Glucophage XR and Fortamet)

1. Decrease hepatic glucose production
2. Reduce intestinal glucose Absorption
3. Increase insulin sensitivity

Basal
What are the side effects of Biguanines:
Metformin side effects are

1. Diarhea, 2. Lactic acidocis
When is Metformin contraindicated?
sCr 1.5 for males and sCr 1.4 for females.
What are the usual doses of metformin?
SD: 500 MD 2500 daily
Which medications are weight neutral?
Metformin, sitagliptin and saxagliptin (DPP-4 inhibitors)
Glipizide, glyburide and glymeperide are all:__________. They work by __________and must be taken_______. Their main sidfe effects are_________
Sulfonyl urea
Stimulating insulin secretion
Basaly
Hypoglucemia and weight gain
The best SU in renal insuficiency is _______. Hupoglycemia is more potenciated with this SFU__________
Glypizide (SD 5mg MD 40 mg)
GLyburide ( SD 2.5-5 mg MD 20 mg)
Meglitanides include________and Repaglinide. They are similar to______however they work _________
Nateglinide and Repaglinide.
Similar to sulfonyl urea mechanistically, they work faster
The side effects of Meglitanides are _______. They inhibit_____________
Hypoglycemia and weight gain.
They inhibit ATP sensitive potassium channels.
Nateglinide and repaglinide must be taken at
meal time.