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7 Cards in this Set
- Front
- Back
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Biguanide - types? |
Metformin |
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Biguanide / Metformin:
Cellular mechanism |
Activates AMP-kinase Decreases hepatic glucose production |
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Biguanide / Metformin: Advantages |
- Extensive experience - No hypoglycemia - Decreases CVD events |
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Biguanide / Metformin: Disadvantages |
- GI side effects --> diarrhea, abdominal cramping - Lactic acidosis - B12 deficiency |
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Biguanide / Metformin: Contraindications |
- CKD - Acidosis - Hypoxia - Dehydration |
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Sulfonylurea - types? |
- Glyburide - Glipizide - Glimepiride |
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Sulfonylurea - Glyburide, Glipizide, Glimepiride Mechanism |
- Closes K-ATP channels on beta-cell plasma membranes - Increases insulin secretion |
