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31 Cards in this Set
- Front
- Back
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What are the 9 patterns of inflammation?
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-Perivascular dermatitis (sup or sup and deep)
-Interface (lichenoid and vacuolar degen) -Spongiotic dermatitis -Psoriasiform dermatitis -Granulomatous dermatitis -Vesiculobullous dermatitis -Vasculopathic reactions -Panniculitis -Folliculitis and perifolliculitis |
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How do you differentiate Hale-hale from Darrier's?
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DArrier's has Dyskeratotic Acantholysis (breaking apart)
hAle-hAle has tons of acantholysis |
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Examples of superficial perivascular inflammation with lymphocytic infiltrate
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Tinea, erythrasma, vitiligo, Schmabergs dz, viral exanthems, urticaria, PIPA
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Causes of superficial perivascular inflammation with PMN infiltrate
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dermatitis herpetiformis
linear IgA Acute Lupus Urticaria LCCV |
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Causes of superficial perivascular inflammation with eosinophilic infiltrate
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BP
pemphigus vulgaris arthropod PUPPP |
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Causes of superficial perivascular inflammation with mast cell infiltrate
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telangiectasias mascularis eruptiva perstans (TMEP)
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What does LCCV look like histologically?
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lymphs and PMNs around vessels
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Examples of Superficial and Deep perivascular
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6Ls:
Light rxns (PMLE and REM) Lymphoma (and Jessner infiltrate Leprosy Lues Lichen Striatus Lupus |
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What does porphyria cutanea tarda look like histologically?
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-subepidermal split (cell poor)
-festooning |
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What diagnosis has subepidermal split with eos?
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BP
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Histo features of erythema multiforme
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-vacuolar degeneration
-necrotic keratinocytes -spongiosis -dermal edema -perivascular lymphs |
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Histo Features of LP
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-hyperkeratosis, no parakeratosis
-hypergranulosis with wedge shaped infiltrate -coloid bodies -liquefaction degen -saw toothed rete ridges -lichenoid lymphs |
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Histo features of necrobiosis lipoidica
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-square punch
-layered cake -plasma cells |
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histo features of trichotillomania
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black stuff in hair follicles
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Characterisitcs of psoriasiform dermatitis
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-epidermal acanthosis
-Elongation of rete ridges -Elongation/prominence of papillary dermal vessels -superficial inflammatory infiltrate (eg Munros microabscesses) |
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What disease has naked granulomas?
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Sarcoidosis
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Examples of granulomatous rxns
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-Sarcoidal (naked)
-tuberculoid (caseating, ie with PMNs) -Palisaded -Foreign body -Suppurative |
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What is the prototypical example of septal panniculitis?
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erythema nodosum
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What does a rheumatoid nodule look like?
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pallisading around fibrin=bright red glob
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What does GA look like?
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pallisading around mucin
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What does PR look like histologically?
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Parakeratosis
Red cells out spongitotic |
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What disease has the hairy palm sign?
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lichen simplex chronicus
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What does lupus look like histo?
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-basal vacuolization (interface derm)
-superficial or sup and deep perivascular and periadnexal inflammation -increased dermal mucin |
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What does DM look like histologically?
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-basal vacuolization
-superficial infiltrate -increased dermal mucn |
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What does morbilliform drug rxn look like histo?
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-spuerficial perivascular mixed infiltrate with eos
-scattered necrotic Kcytes |
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What does Acute GVHD look like histo?
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-basal vacuolization
-mild lymph infiltrate |
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Grade 1 GVHD
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no dyskeratotic cells
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Grade 2 GVHD
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few dyskeratotic cells
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Grade 3 GVHD
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clefts
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Grade 4 GVHD
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complete separation
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What does Chronic GVHD look like histo?
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resembles LP, sclerodermoid
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