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28 Cards in this Set
- Front
- Back
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Nevocellular Nevi:
_____ nevi: between dermis and epidermis ______ nevi: between dermis and epidermis, and goes into dermis _____ nevi: in this layer only |
junctional
compound dermal |
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Nevi variants:
_______ nevus: born with it ____ nevus: pigment is deeper ______ nevus: raised, red papules (ok in kids, bad in adults) _____ nevus: rim of white from immune attacking melanocytes ______ nevus: irregular shape, funny looking |
congenital
blue spitz halo dysplastic |
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Malignant Melanoma:
Most rapidly increasing incidence of cancers No _____ predilection High risk of metastasis with _____ tumors |
gender
thicker |
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Predisposing factors to malignant melanoma:
____ skin UV/solar radiation Familial melanoma syndrome/ ______ nevus syndrome multiple benign nevi larger than _ mm history of severe ______ |
fair
dysplastic 6mm sunburns |
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Clinical Appearance of Melanoma
What are the ABCDEs? |
Asymmetry, border, color , diameter, elevation
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Clark's levels of predicting survival and recurrence of malignant melanoma are based on what?
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thickness - how deep into the itssue the lesion goes
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Melanoma types:
______ spreading nodular ______ maligna ____ lentiginous |
superficial
lentigo acral |
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Tx of malignant melanoma:
Surgical excision Elective ____ ____ dissection sentinel ____ ____ biopsy adjuvant therapy with ______ ____ radiation/chemo Immunotherapy: interferon, IL-_, monoclonal Abs, melanoma vaccines |
lymph node
lymph node Interferon alpha-2b IL-2 |
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Common epidermal benign tumors
Flat, "stuck-on" appearing plaques Tiny horn cyst characteristic |
Seborrheic Keratoses
BENIGN |
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Thickened and hyperpigmented skin
Flexural areas |
Acanthosis Nigricans
"dirty neck" appearance BENIGN |
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Soft, flesh-colored, bag-like tumor
AKA acrochordon, skin tag |
Fibroeptihelial Polyp
BENIGN |
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Rapidly growing crater-like nodule
May represent a form of squamous cell carcinoma |
Keratoacanthoma
BENIGN |
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Eccrine poroma
Cyndroma (apocrine) syringoma (eccrine) Trichoepithelioma (hair follicle) |
Adnexal (appendage) tumors
BENIGN |
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Slight male preponderance
approximately 50% will have additional of these carcinomas in the next 10 years slow growin, locally destructive, rarely metastasize |
Basal cell carcinoma
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Predisposing factors for BCC
___ skin UV/solar radiation Ionizing radiation _________ (basal cell nevus) advancing _____ |
fair
Genodermatoses age |
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____ _____ ______ can be:
nodular superficial/multifocal morpheaform/sclerosing |
basal cell carcinoma
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___ treatment:
Excision Curettage Cryosurgery topical chemo mohs micrographic surgery radiation |
BCC
basal cell carcinoma |
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2:1 male preponderance
5-10% metastasize |
squamous cell carcinoma
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TEST Q:
Actinic keratoses is a precursor for _____ ___ carcinoma. This happens about _% of the time |
Squamous cell carcinoma
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Actinic keratoses, arsenical keratoses, chronic radiation/scar/PUVA keratoses, Bowen's disease, Erytroplasia of Queyrat, Epidermodysplasia verruciformis
These are all precursors for what? |
Squamous cell carcinoma
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Which type of carcinoma has a erythmatous plaque or nodule, often with thicker scale/crust than most BCC, may be eroded/ulcerated, lymph node exam important because they can metastasize
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Squamous cell carcinoma
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High Risk SCC pt:
Recurrent Invades below _____ dermis larger than 2cm poorly _______ arisen in scar or ulcer ________ host location on ___ or ear perineural invasion ____ growth |
reticular
differentiated immunocompromised lip rapid |
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Treat SCC similar to ___
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BCC
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Which carcinoma is this?
Neuroendocrine neoplasm of the skin rare aggressive |
Merkel Cell Carcinoma
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Tumor of the dermis:
tan-brown firm papules often occur on the legs |
Benign Fibrous Histiocytoma
(Dermatofibroma) |
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Tumor of the dermis:
Well-differentiated fibrosarcoma locally aggressive |
Dermatofibrosarcoma Protuberans
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Dermal _____ tumors:
hemangioma angiosarcoma kaposi sarcoma |
Vascular
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Cutaneous Lymphomas can be of what varieties?
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B or T cell
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