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21 Cards in this Set
- Front
- Back
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4 elements of biocompatibility
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No local toxic effects
No toxic components with remote effects No allergenic components No carcinogenic potential |
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Define Type I - IV allergic rx
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Type I: Anaphylaxis
Type II: Cytotoxic hypersensitivity reaction Type III: Immune complex hypersensitivity reaction Type IV: Delayed or cell mediated hypersensitivity reaction |
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Are dental materials shown to be carcinogenic?
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No
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Three levels of evaluation
– Primary Tests – Secondary Tests – Tertiary Tests – Preclinical Usage Test |
Primary Tests: In-vitro and in-vivo test, but not
necessarily related to the use of the materials. Secondary Tests: are more advanced biological test that may be partly related to the use of the material. Usage Tests: are either clinical trials in human or a close model of the use of a material in higher animals. |
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2 toxicity tests tested in primary tests are
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cytotoxicity
genotoxicity |
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In secondary tests, short term tests in what tissue and long term tests in what tissue
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short term - subcutaneous tissue
long term - muscle or bone |
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2 toxicity test of secondary tests are
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systemic toxicity and inhalation toxicity
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systemic toxicity tests
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LD50 (half lethal dose)
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Does skin irritation or sensitization involve antibody activity.
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skin irritation - no Ab activity
skin sensitization - Ab activity |
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T/F: Primary and secondary tests don't necessary relate to the usage of the material.
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T
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3 tertiary (usage) tests
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pulp and dentin usage test
Pulp capping/ pulpotomy tests Endodontic usage tests mucosal and gingival usage test |
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Pulp and dentin usage tests
- animals? - controls? - histology after __, __, __ days |
– Subhuman primates, dogs, miniature pigs
– Positive and negative controls – Histology after 7, 28, 70 days |
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Pulp capping/ pulpotomy tests
- material used as negative control - test periods: __ and __ days |
- CaOH is negative control
– Test period 7 days and 70 days |
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Endodontic usage tests
- material used as control - test periods: __ days or ___ wks |
– ZOE control
– Test period - 28 days/13 wks |
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what does mucosal and gingival usage tests test?
- test periods: __ and __ days - eliminate what before evaluations |
- Reactions to subgingival cavity
preparations and restorations - Histological response after 7 days and 30 days for slight, moderate or severe responses • Eliminate inflammation due to prophylaxis and restorative procedures before evaluations |
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Is primary irritant dermatitis or allergic contact dermatitis dose dependent?
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primary irritant dermatitis - dose dependent
allergic contact dermatitis - non-dose dependent |
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Is prior sensitizing exposure necessary in allergic contact dermatitis?
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yes
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what tests are used to confirm allergic contact dermatitis?
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patch tests
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Is Nickle allergy more common in females or males?
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females b/c they wear more jewelry that contains nickle
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In hypersensitivity, immediate post operative is?
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21 days for return to normal levels of
sensitivity.12 wks sufficient reparative dentin. |
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In hypersensitivity, later post operative pain
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– bond degradation
– polymerization shrinkage & base failure – Cusp deformation – Thermal expansion & contraction |
