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12 Cards in this Set
- Front
- Back
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high grade glioma drug
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temosolomide
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secondary trigeminal neuraligia caused by
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tumor
MS |
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5 things we know about migrane
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1) migrane caused by neuronal excitaiton/ depression spreading slowly across brain from occipital --> fwd
2) throbbing pain caused by sterile trigeminal neuralgia from neuropeptide release 3) allodynia due to central sensitization 4) brainstem generator present 5) genetic: familial hemiplegic hyperexcitability. FHM1 from Ca chan causing increased ec glutamate in cortex |
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active demyelination in MS associated with
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breakdown of blood brain barrier
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marburg's MS
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agressive MS. severe axonal loss. rapid disability and death.
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neuromyelitis optica
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acute or recurrent transverse myelitis with simultaneous optic neuritis
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neuromyelitis optica cells involved
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macrophage infiltration. grey & white matter degeneration
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adrenoleukodystrophy accumulaton of
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very long chain fatty acids
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metachromatic leukodystrophy pathophys
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arylsulfatase mutation. accumulation of galactosylsulfatase (myelin component).
GS accumulates in many cells, path only in CNS/PNS |
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globoid cell leukodystrophy pathophys
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galactocerebrosidase deficience, therefore accumulation of
1)galactocerebroside in microglia & macs 2) psychosine in oligodendrocytes chromosome 14 |
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who gets metachromatic leukodystrophy
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kids, not adults
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globoid cell leukodystrophy sympt
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violent tonic spasms to noises and bright lights
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