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17 Cards in this Set

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  • Back
  • 3rd side (hint)
how does type IV hypersensitivity differ from types I, II, and III?
types I, II, II are Ab-mediated
type IV is mediated by sensitized T lymphocytes
name the 2 subcategories of delayed type hypersensitivity
classical and cytotoxic T cell mediated
characteristics of classical delayed type hypersensitivity
CD4+ Th1 cell
does not destroy antigen directly; recruits macrophages to destroy antigen
characteristics of cytotoxic T cell mediated delayed type hypersensitivity
CD8+ Th1 cell
cytotoxic T lymphocytes destroy antigen directly
what immunologic effector initiates delayed type hypersensitivity?
antigen interacts with TLR on dendritic cell; dendritic cell elaborates IL-12, which causes naive T cell to differentiate down the Th1 pathway
role of IL-2 in delayed type hypersensitivity
clonal expansion of sensitized Th1 cells
role of IL-12 in delayed type hypersensitivity
differentiation of naive T cells to Th1 cells in DTH pathway
role of IFN-alpha and TNF-beta in delayed type hypersensitivity
act on endothelium to increase production of E- and P-selectin as well as ICAM and VCAM to direct lymphocyes and monocytes to roll to and adhere to the endothelium
role of chemokines (CCL-2,3,4,5) in delayed type hypersensitivity
create gradient so lymphocytes and monocytes move into the area
CCL-2 = MCF-1a = monocyte chemotactic factor
main role of IFN-gamma in delayed type hypersensitivity
macrophage activation
secondary roles of IFN-gamma in delayed type hypersensitivity
increased MHC class II molecules
increased IL-12
increased chemokines & chemokine receptors
increased co-stimulatory factors (CD40, CD80)
increases production of 4 things
3 reasons activated macrophages are more efficient killers than resting macrophages
more effective in fusing lysosomes with phagosomes so lysosome contents can be delivered to phagosome
increased NO production to kill microbes
increased production of antimicrobial peptides
what activates macrophages in delayed type hypersensitivity?
what causes differentiation of naive T cells down the Th1 path to delayed type hypersensitivity?
what causes clonal expansion of sensitized T cells in delayed type hypersensitivity?
IL-2 (+ antigen)
what facilitates homing and adhesion of lymphocyes and monocytes to the endothelium in delayed type hypersensitivity?
IFN-alpha and TNF-beta act on endothelium to produce E- and P-selectins; ICAM-1; VCAM-1
what sets up a gradient so that lymphocytes and monocytes move into the area in delayed type hypersensitivity?
chemokines CCL-2,3,4,5
CCL-2 = MCF-1a = monocyte chemotactic factor