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32 Cards in this Set
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- Back
- 3rd side (hint)
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collagen in lamina lucida?
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atypical type IV
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what type of collagen in lamina densa?
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type VII
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Kartagener's syndrome
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dextrocardia and abnl cilial organelles leads to defective mucociliary clearance in bronchi
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Staph SSS vs toxic epidermal necrolysis
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SSSS-supcorneal blister; TEN--subepi blister with confluent necrosis of epi, + Nikolsky sign
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sporadic vs familial porphyria cutanea tarda
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sporadic--enzyme activity dec'd only in liver; familial--activity dec'd in all tissues, including erythrocytes; (enzyme= uroporphyringen decarboxylase)
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typical porphyria cutanea tarda pt?
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40 y/o male with EtOH abuse
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urine test for PCT?
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fluoresces pink to orange-red with wood's lamp
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drug tx for PCT?
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antimalarials (plaquenil)
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macroglossia + carpal tunnel syndrome (and raccoon eyes), think?
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amyloidosis!
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Muir-Torre syndrome
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AD d/o with sebaceous neoplasms, keratoacanthomas, adenocarcinoma of colon (Lynch II!)
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Sweet's syndrome assoc'd with what, esp in elderly?
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APL
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Sweet's syndrome assoc'd with what in kids?
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strep URI
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None
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painful red edematous papules/plaques + fever and peripheral neutrophila=
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Sweet's syndrome
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"satellite" lesions seen in what derm thing?
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candida infection (like diaper rash)
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"spaghetti and meatballs" on KOH
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tinea versicolor
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what is nevus sebaceous?
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"birthmakr", yellow-orange plague on scalp w/o hair; benign hamartoma; gets bigger under hormones
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name the dz: smooth, shiny hairless patch on scalp at birth, may have "hair collar" sign
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aplasia cutis congenita (if hair collar sign--underlying CNS defect!)
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port wine stain vs. "salmon patch"
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pwstain--unilateral, permanent; sp--midline, transient
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Basal cell nevus syndrome
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AD, with BCCs, palmar pitting, mandibular cysts, hypertelorism, bifid ribs, partial agenesis of corpus callosum, , medulloblastoma, ovarian fibromas
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Basal cell nevus syndrome assoc'd with what csome prob?
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9qp22
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retraction artifact
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space seen b/t basal cell islands and surrounding matrix, due to mucopolysaccharides and loss of anchoring fibrils (BCC)
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erythroplasia of Queyrat
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variant of in situ SCC--on genitalia
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what skin cancer often has perineural invasion
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SCC (esp facial n and trigeminal n)
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PTC gene mutation assoc'd with what skin cancer?
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BCC (9q22, basal cell nevus syndrome!)
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what drugs are CONTRAINDICATED for tx of psoriasis?
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systemic corticosteroids (may provoke flare up)
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adverse effects of plaquenil
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GI disturbance, blue-gray hyperpigmentation, OCULAR TOXICITY
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MOA of imiquimod
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activates innate immunity by bidning to TLR which -->IFN
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angiocentric dermatoses
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urticaria (dermal change only!), necrotizing vasculitis
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spongiotic dermatosis ex
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allergic contact dermatitis
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interface dermatosis ex
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discoid lupus erythematous, lichen planus
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histo of discoid lupus
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epidermal atrophy (loss of rete ridge), hyperkeratosis, diffuse lymphocyte infiltrate, pigment incontinence
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basal cell vacuolization, necrotic keratinocytes, pigment incontinence assoc'd with what dermatoses?
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interface (discoid lupus, lichen planus)
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