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47 Cards in this Set
- Front
- Back
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Antinuclear antibodies (ANA)
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SLE, sjogren, many others, nonspecific
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Anti-dsDNA
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SLE
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Anti-Smith DNA
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SLE
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Antihistone
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Drug-induced lupus
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Mechanism of Rheumatoid arthritis?
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Anti-IgG IgM(rheumatoid factor)
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anticentromere
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scleroderma (CREST)
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anti-Scl-70 (anti-DNA topoisomerase I)
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Scleroderma (diffuse)
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antimitochondrial
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primary biliary cirrhosis
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Antigliadin - a component of wheat
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celiac disease
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anti-basement membrane
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Goodpasture's syndrome
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Anti-desmoglein
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Pemphigus Vulgaris
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Antimicrosomal, antithyroglobulin
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Hashimoto's thyroiditis
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Anti-Jo-1
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Polymyositis, dermatomyositis
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Anti-SS-A (Anti-Ro)
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Sjogren, SLE
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Anti-SS-B (Anti-La)
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Sjogren, SLE
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anti-smooth muscle
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autoimmune hepatitis
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anti-glutamate decarboxylase
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Type I DM
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c-ANCA
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Wegener's granulomatosis
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ANCA stands for?
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Anti-neutrophil Cytoplasmic Antibody
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p-ANCA
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microscopic polyangitis, churg-strauss syndrome
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mPO-ANCA
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crescenteric glomerulonephritis
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anti-TSH receptor
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Graves
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anti-Ach receptor
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Myasthenia Gravis
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22q11 deletion
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DiGeorge
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Thymus, parathyroids develop from _____ and _____ pharyngeal pouches
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3rd, 4th
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Absent thymic shadow in
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DiGeorge, SCID
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recurrent viral/fungal infections + positive chvostok sign
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DiGeorge
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Mechanism of Bruton's agammaglobulinemia
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X-linked recessive defect in BTK, a tyrosine kinase gene --> blocks B-cell differentiation/maturation
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Recurrent bacterial infections in a boy after 6 months
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Bruton's agamaglobulinemia
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Triad of SCID?
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Severe recurrent infections, chronic diarrhea, failure to thrive
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Only defense in SCID?
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NK cells
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Gene defect in SCID causes…
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Adenosine deaminase deficiency
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Cell type dysfunction in Chronic mucocutaneous Candidiasis?
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T-cell dysfunction
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Recurrent pyogenic infections, eczema, thrombocytopenia?
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Wiskott-Aldrich (Wiskott, Aldrich Immunodeficiency, Thrombocytopenia and purpura, Eczema, recurrent pyogenic infections- WAITER)
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Poor smooth pursuit of moving target
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Ataxia-telangiectasia
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Defect in DNA repair enzymes leads to increased risk of ______ and ______ , sensitivity to __________in ataxia-telangiectasia
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lymphoma, acute leukemia, X-rays
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Patient presents with bp of 60/40, HR 140, wheezing 15 min after a blood transfusion
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IgA deficiency
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Nitroblue tetrazolium dye remains yellow when mixed with pt. sample
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Chronic Granulomatous Disease
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Chronic Granulomatous disease mechanism?
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Lack of NADPH oxidase
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Pts with chronic Granulomatous disease are susceptible to?
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organisms with catalase - S. aureus, E. coli, Klebsiella, Aspergillus, Candida
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Partial albinism + recurrent respiratory tract and skin infections + neurologic disorders
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Chediak Higashi Disease
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Mechanism of Chediak Higashi Disease?
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defective LYST gene (lysosomal transport) --> giant cytoplasmic granules in PMN's
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Eczema + recurrent cold S. aureus abscesses, course facial features
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Job syndrome
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Mechanism of Job syndrome?
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High levels of IgE, Eosinophils, deficient INF-gamma --> PMN's fail to respond to chemotactic stimuli
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Retained primary teeth resulting in 2 rows of teeth?!
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Hyperimmunoglobulin E syndrome
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Delayed separation of umbilicus
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Leukocyte adhesion deficiency syndrome
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Mechanism of Leukocyte adhesion deficiency syndrome
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abnormal integrins
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