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8 Cards in this Set
- Front
- Back
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Pharmacology of alcohol
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Alcohol is a drug that depresses the CNS
dissolves in lipid membrains alters the cell membranes' anatomy by entering their internal structure Good evidence that alcohol acts on GABA-benzo receptors |
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Pharmacokinetics of alcohol (absorption)
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b/c it provides calories, alcohol is classified as a food, however unlike food it does not have to be digested before the body absorbs it
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Distribution
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after absorption, the blood distributes alcohol to all of the body's tissues
B/c alcohol is easily dissolved by water, the proportion of water in a tissue determines the concentration of alcohol in it. Blood is about 70% water & gets a high concentration of alcohol |
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LD 50
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varies, however the avg. adult would reach alcohol's LD50 after drinking about 25 standard drinks in an hour
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estimated bac equation
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Estimated BAC = NSD x (0.025%) - NHD x (0.015%)
NSD = # of stand. drinks NHD = # of hours since drinking began |
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Why is NSD multiplied by 0.025%?
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b/c that is the midpoint of our estimated range of increase in BAC that results when a 160lb drinker has a stand. drink
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Why is NHD multiplied by 0.015%?
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B/c that is the BAC equivalent of the estimated hourly rate that the liver metabolizes alcohol
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metabolism & excretion
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more than 90% that is absorbed is metabolized by the body, mainly in the liver
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