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18 Cards in this Set
- Front
- Back
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What is the drug used to treat pheochromocytoma and what is its mechanism of action?
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Metyrosine (Demser); its blocks the enzyme that converts tyrosine to DOPA (tyrosine hydroxylase)
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What is the drug used to treat Parkinson's and what is its mechanism of action?
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Carbidopa (Lodosyn); it blocks the enzyme that converts DOPA to dopamine (L-aromatic amino acid decarboxylase)
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What is the drug used to treat alcoholism and what is its mechanism of action?
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Disulfiram (Anatabuse); its blacks the enzyme that converts dopamine to NE (dopamine-beta-hydroxylase)
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What is the false neurotransmitter used to treat hypertension by imitating NE?
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alpha-Methyldopa (Aldomet)
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Reserpine inhibits uptake of _ and _ into synaptic vesicles and is used to treat __ and __.
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dopamine and NE; psychosis and hypertension
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What are the inhibitors of NE reuptake and recycling? What is the therapeutic use of these and which ones are used?
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cocaine, amphetamine, methamphetamine, and tricyclic antidepressants (imiprine, desipramine, amitryptyline, and protryptiline); depression and migraine headaches ->desipramine, amitryptyline, and protriptyline
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MAO-B is especially found in the __ and __ while MAO-A is present in the __ and __.
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brain and platelets; GI and liver
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What are the MAO-A and B inhibitors what what is the therapeutic use?
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tranylcypromine (Parnate) and Phenelzine (Nardil); treat depression and panic disorders
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What are the specific MAO-B inhibitors and wha is their therapeutic use?
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Selegiline (Deprenyl) and Eldepryl; with or w/o L-DOPA in the treatment of Parkinson's
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What is the COMT inhibitor and what is its therapeutic use?
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Entacapone (comtin); used with L-DOPA to treat Parkinson's
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What are the non-selective dopaminergic receptor agonists? Selective?
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Non=dopamine and apomorphine; Selective=fenoldopam (D1) and bromocriptine (D2)
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The cell bodies of the motorneurons of the somatic nervous system are located in the __ horns of the spinal cord.
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anterior
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What is the exception to the rule that the autonomic system has cells bodies in ganglia outside the CNS?
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adrenal medulla
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Which fibers are myelinated in the ANS? Unmyelinated?
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preganglionic; postganglionic
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Which sacral nerves are part of the PNS?
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2,3, and 4
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The SNS has preganglionic nerve fibers that originate in the __ horns of the spinal cord (__ to __).
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lateral; T2 to L2-L3
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What are the transmitter substances in affterent nerves?
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substance P and calcitonin gene related products
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Postganglionic sympathetic nerves that are cholinergic are those that innervate __.
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sweat glands
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