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79 Cards in this Set

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Bone Marrow:
*Primary site of Hematopoiesis;
*site of: B-Cell development;
*site of: Antibody-Production
Thymus:
site of: T-Cell selection & development
Spleen:
*2nd-ary Lymphoid Tissue;
*site of: Antigen Recognition & Lymphocyte clone Proliferation
* site of: Antibody Production
Lymph Nodes:
*2nd-ary Lymphoid Tissue;
*site of: Antigen Recognition & Lymphocyte clone Proliferation
* site of: Antibody Production
Mucosal Lymphatic Tissue:
*2nd-ary Lymphoid Tissue;
*site of: Antigen Recognition & Lymphocyte clone Proliferation
* site of: Antibody Production
T-Cells:
serve as: Helper, Regulator, & Killer cells
B-Cells:
*ANTIBODY-Producing Cells (aka: PLASMA CELLS);
*also act as (APCs) Antigen-Presenting Cells
NK-Cells (Natural Killer):
kill TUMOR cells & VIRUS-infected cells
(APC's) Antigen-Presenting Cells:
*present-->Antigenic-Peptides for T-Cell recognition;
*1)Dendritic Cells,
2) Macrophages, &
3) B-Cells
Dendritic Cells:
*ubiquitous (in tissues & organs)
*Primary (APC) for naive T-Cells
Macrophages:
*derived from: blood Monocytes;
*Highly Phagocytic;
* (APC) antigen-presenting cell
Neutrophils:
*most abundant type of Leukocyte (WBC) in blood;
*Phagocytic;
*Primary cell in ACUTE inflamm.
Eosinophil:
*normally <<3% of blood Leukocytes (WBCs);
*often INCREASE in: ALLERGY & PARASITIC WORM infections
Mast Cells:
*tissue-resident;
*RELEASE---> Histamine & other Pro-inflamm. Mediators
(MHC) Major Histocompatibility- Complex
* Class I & II Molecules;
* identify "Self";
* differences in these Molecules leads to REJECTION of transplanted organ;
* Prim. role= display Antigenic Peptides for T-Cell recognition
CD Molecules:
*a nomenclature system for mainly Cell Surface Proteins that may help classify cell subsets; (EX. CD4 Protein= identifies HELPER T-Cells)
(CAM's) Cell Adhesion Molecule
(*** Ex. INTEGRINS)
*cell-surface molecules that facilitate cell-to-cell signaling;
*also play Maj. role in determining cellular movement & migration
receptors:
*cell-surface GLYCOPROTEINS that bind--> specific Ligands! (Ex. the T-Cell Receptor that binds specifically to an Antigenic Peptide);
*there are also: Fc-receptors, Complement Receptors
Antibody:
*Glycoproteins
produced by: B-CELLS that bind to--> ANTIGEN (Ag);
*IgA, IgD, IgE, IgG, IgM
Cytokines:
*small communication molecules that go btwn. cells
Complement:
*PLASMA PROTEINS that act as: OPSONINS
*facilitate: Inflamm. & Lysis target Microbes
3 Soluble Factors:
1) Antibodies (Ab),
2) Cytokines, &
3) Complement
4 Cell-Surface Proteins:
1) MHC,
2) CD-molecules,
3) CAM,
4) Receptors
5 different Cell Types:
1) Lymphocytes,
2) (APC),
3) Neutrophils,
4) Eosinophils, &
5) Mast Cells
3 types of Lymphocytes:
1) T-cells,
2) B-cells,
3) NK-cells
5 Organs:
1) Bone Marrow,
2) Thymus,
3) Spleen,
4) Lymph Nodes,
5) Mucosal Lymphatic Tissue
CD1
*present--> NON-peptide Antigens(Ag) (Lipid & Glycolipid to some T-Cells) From: 1) Dendritic Cells & 2) Thymocytes
CD2
*Adhesion Molecules that binds CD-58 (on T-Cells, Thymocytes, & NK-Cells)
CD3
*Expressed on: T-Cells & Thymocytes
*signal transduction by the TCR
CD4
*expressed on T-Cell Subset, Monocytes, Macs.
* Signals & adheres Co-receptors that binds to ---> Class II (MHCs)
CD8
*Expressed by: T-Cell Subset & Thymocytes;
*Signaling & Adhesion
CD10
*Expressed by: immature & some mature B-Cells;

*metalloproteinase
CD14
*Expressed by: 1) Monocytes & 2) MACs;
*Binds: LPS + LPS-Binding Protein, Mac-ACTIVATION
CD16a
*Expressed by: 1) NK-Cells, 2)Macs, & 3) Mast Cells
*Immune-Complex-induced cellular Activation;
*ADCC
CD19
*Expressed by: Most B-Cells;
*B-Cell Activation;
*CO-receptor w/ CD21 & CD81
CD20
*Expressed by: ALL B-Cells;
*Activates--> C++Channel & other things unknown
CD21
*expressed by: MATURE B-Cells, EDC;
*Receptor for C3d;
*part of CO-Receptor w/ CD19 & CD81
CD25
*expressed by: ACTIVATED T & B-Cells;
*it is a IL-2 Receptor Alpha-Chain
CD28
*expressed by: T-Cells;
*Binds B7-1 & B7-2 as CO-Stimulator
CD34
*expressed by: Hematopoietic Stem Cells;
*helps w/ Adhesion & Binds to-------->CD62L
CD40
*expressed by: 1) B-Cells, 2)MACs, 3) Dc, & 4) Endothelim
*Binds-->CD40L (on T-Cells) to provide T-cell help;
*Mac-ACTIVATION
CD80
*aka: B7-1
*ON (APC), Binds to--> CD28 to turn T-Cells ON
CD86
*aka: B7-2
*on (APC) binds to---> CD28 to turn T-Cell ON
CD152
*aka: CTLA-4;
*on (APC) binds to---> CD28 to turn T-Cell OFF
CD154
*aka: CD40 Ligand;
*On T-cell Binds to---> B-cell CD40
Histamine:
1) VasoDILATE
2) INCREASE Mucus
Prostaglandins:
1) VasoDILATE
2) INCR. Permeability
Leukotrienes:
1) INCR. Mucus
2) BronchoCONSTRICTION
Chemokines:
*Attract cells to site
(PAF) Platelet-Activating Factor
*CHEMOTAXIS,
Activate---->PMN (Granulocytes)
Enzymatic Mediators:
1) cell movement
2) damage & repair of tissue
C3a, C4a:
*INCR. vasoDILATION,
*INCR. Permeability,
*Anaphylatoxin,
*Phagocyte recruitment
C5a:
*INCR. vasoDILAT. & Permeability,
*Anaphylatoxin,
*chemotactic Factor,
*Phagocyte Recruitment
erythropoietin:
Erythrocytes
(RBCs) Red Blood Cells
(TNF) Tissue Necrosis Factor
*triggers----> Apoptosis
*INCREASE---> (CAM) Fever & Cytokines
IL-1
***Fever
*Activate--->ENDOthelium
(attract Neutrophils)
IL-2
* T-Cell growth,
* T%B Proliferation,
* NK-Proliferation
IL-3
*growth of EARLY Hematopoietic PROGENITOR Cells
IL-4
*made by: TH2;
* B-Cell Proliferation;
* IgE Production
IL-5
*made by: TH2 & Mast Cells;
* B-Cell growth,
* Antibody Secretion,
* Eosinophil-Activation
IL-6:
* Fever, Acute Phase Response
IL-8:
Chemotaxis!!
(Recruit NEUTROPHILS)
IL-10
*made by: Macrophages & TH2
*INHIBITS---> Macrophage & Dendritic Cells
IL-12
*made by: Macrophages & Dendrites;
*Differentiation (of T-cells);
* INCR.---> NK-toxins;
*ANTIangiogenic;
*STIM's---->INF-Gamma & TH1 Production!
IL-17:
*induces---> inflammatory Cytokines & PMN recruitment
INF-alpha:
**Type I
*ANTIviral
INF-beta:
**Type I
*ANTIviral
INF-gamma:
**Type II (2)
*Macrophage & NK-Activation;
*IgG, B, & MHC Production!
G-CSF:
*STIM's----> 1) Granulocytes &
2) Stem Cells
M-CSF:
*STIM's----> 1) Monocytes &
2) Macrophages
GM-CSF:
*STIM's----> 1) Granulocytes &
2) Monocytes
TGF-beta:
*INHIBITORY of: Macrophage
T/B;
*ANTI-inflammatory,
*** IgA
IgM:
**Complement-Activation
IgG:
* Fc-Receptor-Dependent Phagocyte Responses;
*Complement-Activation;
* Neonatal Immunity (Placental transfer)
IgE:
*immunity against Parasites, environmental allergens, Mast Cell DEgranulation (immediate HYPERsensitivity)
IgA:
**Mucosal immunity transfer of IgA through Epithelia
immunoglobulin which is passed through the Placenta?
IgG 1, 2, 3, & 4
Chemokines:
cause cell to move in certain direction
IL-13:
*made by: TH2;
*B-Cell Proliferation;
*IgE Production