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47 Cards in this Set

  • Front
  • Back

IL-1 *

S: Monocytes, macrophaces, DC, fibroblasts, B-cells


T: T cells, B cells, hepatocytes


F: proinflammatory cytokine, lymphocyte activation, macrophage activation, fever, weight loss, hypotony, acute phase reaction

IL-2

S: T cells


T: T cells, NK cells, B cells, monocytes, macrophages, oligodendrocytes


F: T cell proliferation, B cell proliferation, monocyte activation

IL-3

S: activated T cells, mast cells, eosinophils


T: all bone marrow progenitors


F: GF for bone marrow progenitor cells, B cells, monocytes

IL-4

S: mast cells, T cells, bone marrow stroma cells


T: T cells, B cells, monocytes, fibroblasts


F: Isotype switch of B cells, IgG1 and IgE secretion of B cells

IL-5

S: mast cells, T cells, eosinophils


T: eosinophils


F: differentiation of eosinophils, IgA-isotype switch

IL-6 *

S: T cells, B cells, macrophages, bone marrow stroma cells, fibroblasts


T: B cells, PC, T cells, hepatocytes


F: proinflammatory cytokine, B cell differentiation, T cell proliferation, acute phase reaction

IL-7

S: bone marrow and thymic stroma cells, splenic stroma cells


T: T and B cells and progenitors


F: proliferation and maturation of T and B progenitor cells

IL-8 *

S: Activated endothelial cells, monocytes, fibroblasts, keratinocytes, melanocytes, hepatocytes, chondrocytes, tumor cells


T: all immune cells, RBCs, endothelial cells, epithelial cells


F: chemotaxis of all migrating immune cells, activation of neutrophils, inhibition of basophil cell histamine release, blocks IgE secretion, promotes angiogenesis

IL-10 *

S: T cells, monocytes, macrophages, DC


T: B cells, thymocytes, Th1 cells, monocytes, NK cells


F: activation and proliferation of B cells, thymocytes, mast cells

IL-12 *

S: DC, macrophages, B cells


T: T cells, NK cells


F: IFN gamma production of T and NK cells, Th1 cell differentiation

IL-17 *

S: T cells


T: stromal cells, fibroblasts


F: proinflammatory effect

IFN alpha

S: lymphocytes, monocytes, macrophages


T: nearly all cells


F: induction of antiviral defence, inhibition of cell proliferation, regulation of MHC expression

IFN beta

S: fibroblasts, epithelial cells


T: nearly all cells


F: induction of antiviral defence, inhibition of cell proliferation, regulation of MHC expression


IFN gamma *

S: T cells, NK cells


T: monocytes, macrophages, T cells, NK cells, B cells, haemopoietic cells, epthelial cells, tumor cells


F: activation and differentiation of macrophages, T cells, B cells, NK cells, supression of Th2 response

TNF alpha *

S: activated monocytes and macrophages, DC, B cells, T cells, fibroblasts


T: nearly all cells


F: proinflammatory, cytotoxic for neoplastic cells, growth factor for nearly all cells


TNF beta

S: activated B and T cells


T: nearly all cells


F: growth factor for nearly all cells

TGF beta *

= transforming growth factor beta


S: nearly all cells


T: nearly all cells


F: tolerance induction, inhibition of cell proliferation, tissue remodeling

EGF

= epidermal growth factor


S: all ectodermal cells, monocytes, kidney cells


T: nearly all cells


F: wound healing, proliferation of epithelial cells

G-CSF

= ranulocyte colony stimulating factor


S: macrophages, fibroblasts, bone-marrow stroma cells


T: granulocytes, myeloid progenitors, thrombocytes


F: granulocyte and myeloid progenitor activation and proliferation

GM-CSF

=granulocyyte-macrophage colony stimulating factor


S: T cells, macrophages, fibroblasts


T: granulocytes, monocytes, fibroblasts, DC


F: growth factor for haemopoietic progenitors

SCF

= stem cell factor


S: bone marrow stroma cells, brain, liver, kidney, lung, fibroblasts


T: all haemopoietic progenitors (except B cells)


F: growth factor for haemopoietic progenitors

EPO

=erythropoetin


S: liver, kidney


T: erythroid progenitors


F: differentiation and proliferation of erythroid cells

TPO

=thrombopoetin


S: liver, kidney, skeletal muscle


T: megakaryocytes


F: differentiation and proliferation of megakaryocytes

CD1

E: Lanngerhans cell, DC


F: presentation to gamma-delta-TcR

CD3

E: T cell


F: TcR signal transduction

CD4

E: helper T cell


F: T helper cell co-receptor

CD5

E: T cell, B-1 B cell


F: control of signal transduction

CD8

E: cytotoxic T cell


F: cytotoxic T cel co-receptor

CD14

E: monocytes, macrophages, neutrophils


F: LPS receptor, also existing in soluble form

CD16 = Fc-gamma-RIII

E: macrophages, NK cells


F: ADCC

CD19

E: B cell


F: BcR co-receptor

CD21 = CR2

E: B cell


F: BcR co-receptor, complement receptor

CD23 = Fc-epsilon-RII

E: B cells, FDC, Langerhans cells, mast cells


F: inhibition og IgE synthesis

CD25 = IL-2R-alpha

E: activated Treg


F: T and B cell activation

CD28

E: T cell


F: T cell co-stimulation, binds B7

CD32 = Fc-gamma-RII

E: B cell, granulocyte


F: Fc receptor for IgG, inhibition of B cell activation

CD34

E: stem cell, endothel


F: intercellular connections

CD35 = CR1

E: RBC, B cells, FDC


F: complement receptor

CD40

E: B cell


F: germinal center reaction

CD45

E: pan-leukocyte marker


F: phosphatase, signal transduction

CD56

E: NK cell marker


F: adhesion molecule

CD62L = L selectin

E: B cells, T cells, NK cells


F: adhesion molecule, migration

CD80 = B7.1

E: APC


F: T-APC interaction

CD86 = B7.2

E: APC


F: T-APC interaction

CD95 = Fas

E: various cells


F: apoptosis, selection

CD152 = CTLA-4

E: activated T cell


F: inhibition of activation, binds B7 with higher affinity than CD28

CD154 = CD40L

E: activated T cell


F: germinal center raction