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47 Cards in this Set
- Front
- Back
IL-1 * |
S: Monocytes, macrophaces, DC, fibroblasts, B-cells T: T cells, B cells, hepatocytes F: proinflammatory cytokine, lymphocyte activation, macrophage activation, fever, weight loss, hypotony, acute phase reaction |
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IL-2 |
S: T cells T: T cells, NK cells, B cells, monocytes, macrophages, oligodendrocytes F: T cell proliferation, B cell proliferation, monocyte activation |
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IL-3 |
S: activated T cells, mast cells, eosinophils T: all bone marrow progenitors F: GF for bone marrow progenitor cells, B cells, monocytes |
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IL-4 |
S: mast cells, T cells, bone marrow stroma cells T: T cells, B cells, monocytes, fibroblasts F: Isotype switch of B cells, IgG1 and IgE secretion of B cells |
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IL-5 |
S: mast cells, T cells, eosinophils T: eosinophils F: differentiation of eosinophils, IgA-isotype switch |
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IL-6 * |
S: T cells, B cells, macrophages, bone marrow stroma cells, fibroblasts T: B cells, PC, T cells, hepatocytes F: proinflammatory cytokine, B cell differentiation, T cell proliferation, acute phase reaction |
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IL-7 |
S: bone marrow and thymic stroma cells, splenic stroma cells T: T and B cells and progenitors F: proliferation and maturation of T and B progenitor cells |
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IL-8 * |
S: Activated endothelial cells, monocytes, fibroblasts, keratinocytes, melanocytes, hepatocytes, chondrocytes, tumor cells T: all immune cells, RBCs, endothelial cells, epithelial cells F: chemotaxis of all migrating immune cells, activation of neutrophils, inhibition of basophil cell histamine release, blocks IgE secretion, promotes angiogenesis |
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IL-10 * |
S: T cells, monocytes, macrophages, DC T: B cells, thymocytes, Th1 cells, monocytes, NK cells F: activation and proliferation of B cells, thymocytes, mast cells |
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IL-12 * |
S: DC, macrophages, B cells T: T cells, NK cells F: IFN gamma production of T and NK cells, Th1 cell differentiation |
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IL-17 * |
S: T cells T: stromal cells, fibroblasts F: proinflammatory effect |
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IFN alpha |
S: lymphocytes, monocytes, macrophages T: nearly all cells F: induction of antiviral defence, inhibition of cell proliferation, regulation of MHC expression |
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IFN beta |
S: fibroblasts, epithelial cells T: nearly all cells F: induction of antiviral defence, inhibition of cell proliferation, regulation of MHC expression |
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IFN gamma * |
S: T cells, NK cells T: monocytes, macrophages, T cells, NK cells, B cells, haemopoietic cells, epthelial cells, tumor cells F: activation and differentiation of macrophages, T cells, B cells, NK cells, supression of Th2 response |
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TNF alpha * |
S: activated monocytes and macrophages, DC, B cells, T cells, fibroblasts T: nearly all cells F: proinflammatory, cytotoxic for neoplastic cells, growth factor for nearly all cells
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TNF beta |
S: activated B and T cells T: nearly all cells F: growth factor for nearly all cells |
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TGF beta * |
= transforming growth factor beta S: nearly all cells T: nearly all cells F: tolerance induction, inhibition of cell proliferation, tissue remodeling |
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EGF |
= epidermal growth factor S: all ectodermal cells, monocytes, kidney cells T: nearly all cells F: wound healing, proliferation of epithelial cells |
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G-CSF |
= ranulocyte colony stimulating factor S: macrophages, fibroblasts, bone-marrow stroma cells T: granulocytes, myeloid progenitors, thrombocytes F: granulocyte and myeloid progenitor activation and proliferation |
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GM-CSF |
=granulocyyte-macrophage colony stimulating factor S: T cells, macrophages, fibroblasts T: granulocytes, monocytes, fibroblasts, DC F: growth factor for haemopoietic progenitors |
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SCF |
= stem cell factor S: bone marrow stroma cells, brain, liver, kidney, lung, fibroblasts T: all haemopoietic progenitors (except B cells) F: growth factor for haemopoietic progenitors |
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EPO |
=erythropoetin S: liver, kidney T: erythroid progenitors F: differentiation and proliferation of erythroid cells |
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TPO |
=thrombopoetin S: liver, kidney, skeletal muscle T: megakaryocytes F: differentiation and proliferation of megakaryocytes |
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CD1 |
E: Lanngerhans cell, DC F: presentation to gamma-delta-TcR |
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CD3 |
E: T cell F: TcR signal transduction |
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CD4 |
E: helper T cell F: T helper cell co-receptor |
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CD5 |
E: T cell, B-1 B cell F: control of signal transduction |
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CD8 |
E: cytotoxic T cell F: cytotoxic T cel co-receptor |
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CD14 |
E: monocytes, macrophages, neutrophils F: LPS receptor, also existing in soluble form |
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CD16 = Fc-gamma-RIII |
E: macrophages, NK cells F: ADCC |
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CD19 |
E: B cell F: BcR co-receptor |
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CD21 = CR2 |
E: B cell F: BcR co-receptor, complement receptor |
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CD23 = Fc-epsilon-RII |
E: B cells, FDC, Langerhans cells, mast cells F: inhibition og IgE synthesis |
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CD25 = IL-2R-alpha |
E: activated Treg F: T and B cell activation |
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CD28 |
E: T cell F: T cell co-stimulation, binds B7 |
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CD32 = Fc-gamma-RII |
E: B cell, granulocyte F: Fc receptor for IgG, inhibition of B cell activation |
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CD34 |
E: stem cell, endothel F: intercellular connections |
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CD35 = CR1 |
E: RBC, B cells, FDC F: complement receptor |
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CD40 |
E: B cell F: germinal center reaction |
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CD45 |
E: pan-leukocyte marker F: phosphatase, signal transduction |
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CD56 |
E: NK cell marker F: adhesion molecule |
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CD62L = L selectin |
E: B cells, T cells, NK cells F: adhesion molecule, migration |
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CD80 = B7.1 |
E: APC F: T-APC interaction |
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CD86 = B7.2 |
E: APC F: T-APC interaction |
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CD95 = Fas |
E: various cells F: apoptosis, selection |
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CD152 = CTLA-4 |
E: activated T cell F: inhibition of activation, binds B7 with higher affinity than CD28 |
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CD154 = CD40L |
E: activated T cell F: germinal center raction |