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18 Cards in this Set
- Front
- Back
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IL-1
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Macrophage->endothelium, lymphocyte, local cell destruction
-inflammatory response, activates lymphocytes, self-induces IL-6 -causes fever |
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IL-2
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T-cell->T-cell, B cell, NK
-activates naive T-cells--proliferate -induces B cell, NK proliferation -Induces B cell antibody production |
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IL-4
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Th2-->T-cell, B-cell
-Th2 produces IL-4 to make more Th2 (initial IL-4 release unknown) -Induces IgE and IgG production in B-cells |
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IL-5
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Th2->B cells, macrophages
-Stimulates release of IgM, IgA -macrophage inhibition |
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IL-6
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Macrophage, T cell, endothelium->lymphocyte
-lymphocyte activation, increase antibodies -increase liver protein production -causes fever |
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IL-8
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Macrophage, epithelium ->leukocytes
-(CXCL8) chemokine that attracts leukocytes to infection site |
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IL-12
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Macrophage->NK cell, T cells
-activates NK cells -induces IFN-gamma production -inhibits memory cell proliferation -stimulates Th1 proliferation |
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IL-15
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Macrophage-> B cells, T cells
-proliferation of memory B and T cells -proliferation of NK cells |
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INF-gamma
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NK cells, CD8, CD4->Macrophage, B cell, APC
-activates APCs to express MHCII -induces B cell IgG class switch -antiproliferative to Th2 |
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TNF-alpha
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Macrophage-> endothelium
-make platelet activating factor (pro-clotting) -causes inflammation, permeability, fever, weight loss -neutrophil activating |
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INF-alpha, beta
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-released by cells that possess viral repeat components
-stimulate NK cells to secrete perforin/granzymes -prevents viral replication -viral resistance nearby |
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TGF-beta
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T-regs
-anti-inflammatory |
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IL-10
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T-regs, macrophage
-anti-inflammatory (inhibits IFN-gamma production) -induces B cell proliferation |
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FoxP3
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T-regs
-transcription factor. negative transactivator of IL-2 -deletion results in autoimmunity, inflammation, allergies |
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GM-CSF
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Granulocyte monocyte colony stimulating factor
-Released by Th1, Th2 -increases neutrophils and monocytes |
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IL-3
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T cells->pluripotent marrow
-T cell differentiation from bone marrow during immune response |
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Prostaglandin
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made by mast cells
-cause permeability, vasodilation -production inhibited by Aspirin |
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Leukotriene
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released by mast cells, basophils
-mediator of vasodilation/permeability, broncho-constriction, diarrhea |
