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11 Cards in this Set

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IL-1
from macrophages

causes fever and inflammation
endothelial adhesion molecule expression
chemokine secretion for leukocytes
IL-2
from Th1 cells

stimlates Th/Tc growth
IL-3
from all T cells

supports bone marrow stem cells
like GM-CSF
IL-4
from Th2 cells

promotes IgE/IgG class switching
promotes Th2 differentiation
IL-5
from Th2 cells

promotes IgA class switching
stimulates eosinophils
IL-6
from macrophages and Th

causes fever and acute-phase protein production
IL-8
from macrophages

neutrophic chemotactic factor
IL-10
from Th2 and regulatory T cells

modulates inflammation (similar to TGF-beta)
inhibits T cells and Th1
activates Th2
IL-12
from macrophages and B cells

induces Th1 differentiation
activates NK cells
Interferon-gamma
from Th1 cells

activates macrophages and Th1
supresses Th2 cells
antiviral/antitumor
TNF-alpha
from macrophages

causes septic shock
endothelial activation, leukocyte recruitment, and vascular leakage