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24 Cards in this Set
- Front
- Back
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IL-1
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Secreted by Macrophage
Activates lymphocytes, produces fever |
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IL-2
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Secreted by T Cells
T Cell Proliferation, Ig synthesis by B Cells, increase NK activity |
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IL-3
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Secreted by Th1 Cells
Growth and Differentiation of Hematopoietic cells (both myeloid and lymphoid) |
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IL-4
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Secreted by Th2, Mast Cells, Basophils
Differentiation of Th2 Cells, activation of B Cells, class switch to IgE/IgG, T Cell growth factor |
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IL-5
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Secreted by Th2
B Cell Differentiation |
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IL-6
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Secreted by Th2 Cells and Macrophages
Activate T & B Cell differentiation, produce fever, release acute phase proteins from liver |
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IL-7
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Secreted by Stromal Cells
B and T Cell development in marrow, T Cell growth factor, survival signal for memory T cells |
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IL-10
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Secreted by Regulatory T Cells (Treg) and Th2 Cells
Immunosuppression, interfere with Th1 differentiation |
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IL-12
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Secreted by Macrophages and dendritic cells
Activate NK Cells, differentiation of Th1 Cells |
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IL-15
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Secreted by many non-T Cells
T cell growth factor, survival signal for memory T cells |
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TNF-alpha
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Secreted by Macrophages and Th1 Cells
Increase permeability and activate vascular endothelium, Mobilize dendritic cells to secondary lymphoid tissue, cause fever, mobilize metabolites and neutrophils |
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LT-alpha (TNF-beta)
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Secreted by Th1
Activate endothelium to attract macrophages |
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CD40L
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Secreted by T cells
Activate B Cells to make antibody, activate macrophages to kill intracellular pathogens |
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Fas Ligand
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Secreted by T Cells
Apoptosis following immune response and during T cell development |
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IFN-alpha/beta (Type I)
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Secreted by any virus-infected cell
Increase resistance to viral infection, increase susceptibility to killing via Ag presentation, activate NK cells |
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IFN-gamma (Type II)
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Secreted by Th1, Tc, NK Cells
Activate macrophages to kill intracellular pathogens, increase resistance to viral infection, increase susceptibility to killing via Ag presentation, differentiation of Th1 Cells, interfere with Th2 differentiation, class switch to opsonizing and complement fixing antibodies |
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G-CSF
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Secreted by Fibroblasts and Monocytes
Neutrophil development and differentiation in marrow |
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M-CSF
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Monocyte development and differentiation in marrow
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GM-CSF
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Secreted by T Cells and Macrophages
Granulocyte and monocyte differentiation in marrow |
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SCF (Stem Cell Factor)
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Secreted by Stromal Cells
B and T Cell Development in marrow |
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TGF-beta
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Secreted by Regulatory T Cells, Th2, Monocytes, and Chondrocytes
Immunosuppression, interfere with Th1 differentiation, class switch to IgA |
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CXCL-8 (IL-8)
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Secreted by Macrophages
Chemotaxis of Neutrophils to site of infection |
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CCL2
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Secreted by Th1 Cells
Macrophages move to site of infection |
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CCL19/CCL21/CXCL13
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Secreted by Dendritic Cells, Stromal Cells, HEV
Homing in lymph node of B, T, and Dendritic Cells |
