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69 Cards in this Set
- Front
- Back
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Interleukin (IL)-1 Secreted By:
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monocytes, macrophages, B-cells, dendritic cells, endothelial cells, others
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Interleukin (IL)-1 Target Cells/Tissues
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TH cells, B-cells, NK cells, Endothelial cells, macrophages and neutrophils, hepatocytes, hypothalamus
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Interleukin (IL)-1--->TH Cells--->FXN:
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co-stimulates activation
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Interleukin (IL)-1--->B-Cells--->FXN:
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promotes maturation and expansion
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Interleukin (IL)-1--->NK Cells--->FXN:
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enhances activity
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Interleukin (IL)-1--->Hepatocytes--->FXN:
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induce synthesis of acute phase proteins
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Interleukin (IL)-1--->Hypothalamus--->FXN:
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induces fever
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IL-2 Secreted By:
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TH cells
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IL-2 Target Tissues
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antigen primed TH and CTLs
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IL-2--->TH/CTL--->FXN:
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induces proliferation, enhances activity
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IL-3 Secreted By:
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TH cells, NK cells
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IL-3 Target Cell/Tissue:
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Hematopoietic (myeloid) cells
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IL-3 Activity on Hematopoietic (myeloid) Cells:
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Supports growth and differentiation
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IL-4 Secreted By:
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TH2 cells
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IL-4 Target Cell/Tissues:
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1. Antigen primed B-cells
2. Activated B-cells |
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IL-4 Activity on Ag Primed B-cells:
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Costimulates activation
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IL-4 Activity on Activated B-cells:
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Stimulates proliferation and differentiation induces class switch to IgG1 and IgE
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IL-5 Secreted by:
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TH2 cells
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IL-5 Target Cells/Tissue:
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Activated B-cells
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IL-5 Activity on Activated B-cells:
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Stimulates proliferation and differentiation, induces class switch to IgA.
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IL-6 Secreted By:
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Monocytes, macrophages, TH2 cells, bone marrow stromal cells.
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IL-6 Target Cells/Tissues:
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Proliferating B-Cells and
Plasma Cells Myeloid stem cells Hepatocytes |
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IL-6 activity on Proliferating B-cells:
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Promotes terminal differentiation into plasma cells
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IL-6 activity on Plasma cells:
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Stimulates AB secretion
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IL-6 activity on Myeloid Stem Cells:
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Helps promote differentiation
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IL-6 activity on hepatocytes:
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Induces synthesis of acute phase reactants.
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IL-7 Secreted By:
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Bone marrow
Thymic stromal cells |
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IL-7 Target Cell/Tissue:
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Lymphoid stem cells
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IL-7 activity on Lymphoid Stem Cells:
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Induces differentiation into progenitor B and T cells
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IL-10 Secreted By:
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TH2 Cells
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IL-10 Target Cell/Tissue:
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Macrophages
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IL-10 Activity on Macrophages:
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Suppress cytokine production by TH1 cells
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IL-8 Secreted By:
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Macrophages
Endothelial cells |
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IL-8 Target Cell/Tissues:
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Neutrophils
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IL-8 activity on Neutrophils:
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Chemokine, induces adherence to endothelium and extravasation into tissues
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IL-12 Secreted By:
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Macrophages
B-cells |
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IL-12 Target Cell/Tissues:
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Activated CD8+ cells
NK, LAK, and activated TH1 cells |
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IL-12 Activity on Activated CD8+ cells:
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Acts synergistically with IL-2 to induce differentiation into CTLs
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IL-12 Activity on NK, LAK, and activated TH1 cells:
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Stimulates proliferation
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inf-alpha secreted by:
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Leukocytes
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INF-α target cells/tissues:
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uninfected cells
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INF-α activity on uninfected cells:
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inhibits viral replication
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INF-β secreted by:
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fibroblasts
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INF-β target cells/tissue:
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uninfected cells
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INF-β activity on uninfected cells:
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inhibits viral replication
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INF-γ secreted by:
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TH1, CTLs, NK cells
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INF-γ Target Cell/Tissue:
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Macrophages
Many cell types Proliferating B-cells TH2 cells Inflammatory cells |
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INF-γ activity on macrophages:
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enhances activity
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INF-γ activity on many cell types:
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increases expression of classes I and II MHC
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INF-γ activity on proliferating B-cells:
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induces class switch to IgG2a, blocks IL-4 induced class switch to IgE and IgG1
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INF-γ activity on TH2 cells:
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inhibits proliferation
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INF-γ activity on inflammatory cells:
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mediates effects important in DTH (delayed type hypersensitivity or Type IV hypersensitivity)
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Transforming growth factor-β secreted by:
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platelets, macrophages, lymphocytes, mast cells.
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TGF-β target cell/tissue:
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Proliferating B-cells
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TGF-β activity on proliferating B cells:
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induces class switch to IgA
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TNF-α secreted by:
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macrophages, NK cells
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TNF-α target cells/tissues:
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tumor cells
inflammatory cells |
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TNF-α activity on tumor cells:
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has cytotoxic effect
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TNF-α activity on inflammatory cells:
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induces cytokine secretion, causes cachexia of chronic inflammation
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TNF-β secreted by:
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TH1 and CTL
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TNF-β target cell/tissue:
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tumor cells
macrophages and neutrophils |
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TNF-β activity on tumor cells:
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cytotoxic effects
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TNF-β activity on macrophages and neutrophils:
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enhances phagocytic activity
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by:
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macrophages and TH-cells
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GM-CSF target cell/tissue:
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bone marrow granulocyte and macrophage precursors
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GM-CSF activity on bone marrow granulocyte and macrophage precursors:
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induces proliferation; used clinically to counteract neutropenia following ablative chemotherapy
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Granulocyte-colony stimulating factor (G-CSF) secreted by:
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macrophages and TH-cells
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G-CSF target cell/tissue:
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bone marrow granulocyte precursors
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G-CSF activity on bone marrow granulocyte precursors:
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induces proliferation; used clinically to counteract neutropenia following ablative chemotherapy
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