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18 Cards in this Set
- Front
- Back
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Statin with highest efficacy
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rosuvastatin
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First line therapy for lower LDL
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statins (HMG CoA reductase)
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When should statins be d/c?
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when LFTs exceed 3x/normal
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Which statins are processed by CYP3A4 in liver?
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simvastatin
atorvastatin Lovastatin cerivastatin |
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Which statin is broken down by both liver and renal?
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pravastatin
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Which statins are metabolized by CYP2C9?
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rosuvastatin
fluvastatin |
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2nd line therapy for lowering LDL-C
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bile-acid sequestrants
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General mechanism of bile-acid sequestrants
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BASs bind to bile acids and excrete through stool
liver then takes up chol to make more BAs (also inc # of hepatic LDLR) |
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A side effect of chol processing of bile-acid sequestrants
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compensatory induction of HMG-CoA reductase activity
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Tx for familial hypercholesterolemia
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bile-acid sequestrants AND statin
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First line therapy for inc levels of HDL
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niacin (nicotonic acid)
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Absorption of which medications can be affected by bile acid sequestrants?
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digitalis
thiazides warfarin aspirin |
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Main side effect of niacin
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hot flushes
(also shown to inc birth defects in lab animals) |
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first line therapy for lowering TGs
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fibric acid derivatives (Lopid or Tricor)
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Preliminary lipoprotein for inc HDL
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ApoA1
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Why are statins and fibrins not used together?
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inc risk of rhabdomyolysis
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Mechanism of mipomersen
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antisense therapeutic that targets mRNA for apolipoprotein B
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CETP inhibitors do what?
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inc HDL (70-100%)
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