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18 Cards in this Set
- Front
- Back
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Number one cause of mortality in ICU?
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Septic Shock
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Mortality rate for septic shock?
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20-30%
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Septic shock is ___ leading cause of death
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10th
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T/F any organism can cause sepsis?
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truth
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Explain the course of sepsis, from bacterial infection to shock
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infection- bacteremia- host inflammatory response- increased inflamm/coagulation and decreased fibrinolysis- change in endothelium/microvasc/BP- shock and organ failure
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whats SIRS?
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systemic inflammatory response syndrome
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what's sepsis?
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SIRS due to infection
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in order for something to be characterized as "sepsis syndrome" what needs to be involved
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sepsis (duh fuckhead) and:
hypotension or altered organ perfusionb: hypoxemia, elevated lactate, oliguria, or altered mental status |
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septic shock is defined as
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sepsis syndrome with refractory hypotension
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Multiple Organ dysfunction is defined as
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altered organ function in acutely ill patient such that homeostasis cannot be maintained w/o intervention
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Name some common bacterial agents that cause sepsis
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Gram negative rods, encapsulated pyrogens, staph, beta-hemolytic strep, anaerobes
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pseudomonas are gram ____ and oxidase
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negative; positive
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what are some characteristics of a pt with sepsis due to pseudomonas infection
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immunocompromised usually, neutropenic, usually have a higher mortality
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Whats a lesion seen in a minority of pts with sepsis caused by pseudomonas
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ecthyma gangrenosum
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What receptor marks the beginning of the inflammatory cascade for sepsis
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TLR4
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There are 4 Cardiovasulcar/hemodynamic aspects in sepsis...gimme it
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1. initial vasdilation/capillary leakage- dec PVR so compensatory CO
2. marked hypotension that can be treated with vol replacement but then becomes refractory 3. Generalized CV insufficiency from maldistribution of blood, endothelial damage, hypoperfusion 4. coagulation abnormal with organ damage |
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Sepsis- tx guideline for shock and organ failure
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stabilize/reverse CV and metabolic problems, fluid replacement, vaso/cardioactive drugs
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What are the invasive procedures involved in treating sepsis?
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draining abcess, debribing necrotic tissue, remove colonized shit like catheters
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