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10 Cards in this Set
- Front
- Back
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Pathogenesis of MI |
Occlusive intracoronary thrombus -
Vasospasm Emboli - |
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Normal myocardium |
Cross striations Central nuclei Pale pink intercalated disks |
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Changes with MI |
Pink contraction bands Loss of striations Infiltration of neutrophils Healing: collagen deposits |
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What is an aneurysm? |
weak walls may burst leading to severe loss of blood (haemorrhaging) Brain aneurysm is called a stroke |
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What is MI? |
When a coronary artery is totally blocked by a thrombus/embolus No blood supply to heart muscle and cells die - often fatal |
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What is angina? |
Chest pain due to severe shortage of blood to the heart muscle - cells do not die Caused by narrowing of coronary arteries (atherosclerosis) |
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Which troponins are released? Advantage |
I and T High specific for myocardial injury Exclude CK elevations with skeletal muscle trauma. |
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What are contraction bands? |
unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture |
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Blood vessel layers
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Tunica intima - endothelial cell lining Tunica media - smooth muscle cells, Tunica adventitia- loose collagenous fibres, blood vessels |
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Layers in heart wall |
Epicardium Myocardium Endocardium - v. thick in atria, thin in ventricle. |
