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34 Cards in this Set

  • Front
  • Back
Organelle from which genetic information is transcribed into RNA for use in protein synthesis in the cytoplasm
nucleus
has these major components: chromatin, nuclear matrix, nuycleoli, and nuclear membrane
nucleus
where ribosomal DNA is transcribed into ribosomal RNA
nucleolus
where you'd find chromosome tips
nucleolus.. tips of ~5 pairs of our chromosomes have the rRNA genes that the nucleolus will use DNA and transcribe it to rRNA
recognizable in EM by fibrillar (DNA transcribing RNA) and granular appearance (maturing ribosomes)
nucleolus
structure continuous with the perinuclear cistern
RER
carries out the TCA, fatty acid cycle, and urea cycle
mitochondria
the amount of this organelle in a cell woudl correlate to the oxidative energy requirements
mitochrondria
functions as a protected site for the synthesis of the polypeptide chain encoded in the mRNA and to participate in the assembly of the proper aa necessary to form this protein
ribosome
these translate proteins associated with the cell's own use
free polysomes (ribosomes)
these are associated with synthesis of proteins for export AND with synthesis of integral membrane proteins
attached polysomes (RER ribosomes)
an important function is to serve as the entrance to the vesicular transport pathway
SER and RER
synthesis of membrane proteins
RER
synthesis of secreted proteins and proteins destined for the lumen of various organelles such as peroxisomes lysosome and golgi
RER
phopholipid syntehsis, cholesterol syntehsis, steroid hormone synthesis
SER
detoxification and the regulation of cytoplasmic calcium levels
SER
important in muscle cells for the regulation of calcium ion concentration
SER or in this case known as the sarcoplasmic reticulum
high concentration of this organelle in leydig cells which are in the testis and involved in synthesis of the testosterone
testosterone is a steroid hormone

SER
responsible for directing proteins to their proper locations
GA
responsible for modifying secretory lysosomal and some membrane proteins
GA
usually found together with the nucleus and centrioles because of its importance in proper cell function
GA
enzymes in the _______ glycosylate the protein by addition of oligosaccharides. This core glycosylation is N linked to asp. In the ___________ many of the sugars are removed before other residues such as fucose and sialic acid are added (terminal glycosylation)
RER
GA

The particular pattern of added sugars seems to be an important signal giving the address for the final destination of the protein
the cell's waste processing and recycling centers
lysosomes
_______ is caused by exposure to injury, cancer, toxins, and inflammation and is characterized by DNA hydrolysis and cell lysis
cell death/necrosis
what are the two kinds of PCD
apoptosis type I
autophagy type II
_____ invovles a sequence of biochemical events leading to a characteristic cell morphjology and death
apoptosis
______ is engulfment of cells of debris before PCD
autophagy
what is the difference between necrosis and PCD
necrosis damages the organism where PCD does not
what are the morphological hallmarks of apoptosis
cell and nuclear shrinkage
nuclear condensation and fragmentation
name three times when apoptosis occurs in the body
during embryo (get ride of webbed feet)
throughout live (hematopoietic system)
reproduction (hormonal, mammary glands)
what regulates apoptosis?
caspase activators
caspase inhibitors
give two examples of apoptosis gone wrong.
cancer
degenerative diseases like PD
what plays a role in cell survival during starvation
autophagy (PCD type II) because organelles are recycled to provide nutrients to the cell
T or F. autophagy occurs in the absence of caspase activity in several mechanism
autophagy