Crrab Ii Froberg Respiratory Pathology

Front 1

–First RED then GREY hepatization of lung
–AVEOLAR INFILTRATE leads to CONSOLIDATION
–Abrupt onset; productive cough

Back 1

Lobar Pneumonia

aka CAP

Front 2

–FOCAL CXR findings
–Insiduous onset with productive cough

Back 2

Bronchopneumonia

aka HAP/HCAP

Front 3

–VESICULAR CXR
–Insidious onset, Non-productive (dry) cough

Back 3

Atypical pneumonia

(Viral, Mycoplasma pneum.)

Front 4

–Bug prevents Phagosome fusion
–Dieterle's Silver stain

–Elderly female smokers w/HIV get bad pneumonias
– water loving Gram- rod

Back 4

Legionella

Front 5

–Exotoxin A (like diphtheria toxin) blocks ptn syn.
–Phospholipase C degrades DPPD and lyses RBCs

Back 5

Pseudomonas

Front 6

Risks:
1.) Cystic Fibrosis
2.) Neutropenia
3.) Severe burns

Back 6

Risk factors for Pseudomonas

Front 7

–Reactive LYMPHOCYTOSIS (Mø's even tho you'd expect PMNs)
–Attaches to cilia & kills w/cytotoxin

–Gram- rod
–DPT vax is best tx

Back 7

Bordetella PERTUSSIS

WHOOPING COUGH

Front 8

Toxin MOA:
A___________
B___________
Corynebacterium
Diphtheriae
E___________
F___________
G___________

Back 8

ADP-ribosylation
Beta-prophage
C
D
Elongation
Factor 2
Granules

Front 9

–G+ club shaped rod on tellurite agar
–PSEUDOMEMBRANE pharyngitis
–Toxiod vax prevention

Back 9

Corynebacterium Diphtheriae

"Coryne" = "club shaped"

Front 10

–Polyribitol phosphate capsule
–Quelling + (duh!)
–Hib vax prevents meningitis, epiglottitis

Back 10

H. Influenzae

Front 11

–IgA Protease
–Factor V and Factor X
–Chocolate agar
–Treat with Ceftriaxone (3rd gen)

Back 11

H. Influenzae

Front 12

–Dense inflammatory infiltrate meningitis
–Most important virulence factor is the polysaccharide capsule

Back 12

H. Influenzae

Front 13

–Interstitial pneumonitis (Mø's)
–Non-productive cough (duh!)
–No consolidation
–Teenagers, cold agglutinins

Back 13

Mycoplasma pneumonia

Front 14

–Fibrin rich HYALINE (alveolar) MEMBRANES
–PMNs cause damage





–diffuse alveolar damage; V/Q problems
–Aspiration, trauma, sepsis, shock,

Back 14

ARDS

Acute Respirtory Distress Syndrome

Front 15

–Partial immunity
–"Partly remember last years virus"
–Point mutations

DRIFT OR SHIFT?

Back 15

Antigenic DRIFT

Front 16

–Two strains infect same cell
–H&N reassortment
–RNA recombination

DRIFT OR SHIFT?

Back 16

Antigenic SHIFT

Front 17

–RNA SS- sense virus
–Very CONTAGIOUS
–Infections 'nose to bronchiole'
–Mucosal necrosis w/ polykaryons

Back 17

RSV

Respiratory Syncytial Virus


15% fatality rate in pts w/:
Chemo
Congenital heart dx
Lung dx

Front 18

–Nonenveloped DNA virus
–Cowdry Type A bodies

Back 18

Adenovirus

Front 19

–Pharyngoconjunctival fever
–Intranuclear, eosinophillic inclusions with halo (no polykaryons)

Back 19

Adenovirus

Front 20

–Usually in WINTER in kids
–Can be fatal if concurrent illness (ARDS)
–Mucosal sloughing and polykarons present

Back 20

RSV

(polykaryons are multi nucleated things)

Front 21

–50% mortality
–Deer mouse vector
–Ribavirin may help

Back 21

Hanta virus

(sin nombre virus?)

Front 22

Coronavirus causes two well known diseases:

1.) The common cold
2.) ______________

Back 22

SARS

Severe Acute Respiratory Syndrome (civet vector)

Front 23

–F protein (fusion) and H protein (hemagglutin) help bind virus and aid cell entry

–PROMINENT POLYKARYONS

Back 23

Measles (Rubeola)









(paramyxovirus family)

Front 24

–RNA SS- sense virus
–Warthin-Finkeldey cells w/nucl and cytoplasmic inclusions
–causes Koplik spots (oral), Conjuntivitis, and Resp. sxs

Back 24

Measles (Rubeloa)









(paramyxovirus family)

Front 25

Most common life threatening complication to transplantation?

Back 25

CMV inclusion disease

Pneumonia
Encephalitis
GI ulcers

Chorioretinitis (eye)

Front 26

There are two "receptor deficits" that will guarantee a more severe TB infection. They are:

1.) ________________
2.) ________________

Back 26

1.) IFN-g receptor
2.) IL-12 receptor









*Note*IFN-g dfx causes impaired granuloma formation and IL-12 dfx causes decreased IGN-g production

Front 27

Animal studies have shown that _______ is essential to CTL cells for control of TB infection.

Back 27

NOS is necessary to control TB






(Recall: Aminoguanidine, an NOS inhibitor, causes TB reactivation in mice)

Front 28

What is scrofula?

Back 28

Scrofula = TB neck nodes

Front 29

–SMALL intracellular YEAST
–No capsule
–Ohio/Mississippi river valley

Back 29

Histoplamosis

Front 30

–LARGE free YEAST
–double refractile wall
–Namekagon fever (WI)

Back 30

Blastomycosis

Front 31

–Broad based buds
–Ohio river valley
–TB look alike

Back 31

Blastomycosis

Front 32

–Target lesions
–Septae Branching Hyphae

Back 32

Aspergillosis

Front 33

–Inhale spherules with dust/sand
–San Joaquin Valley fever

Back 33

Coccidiomycosis

Front 34

–Addison's, anema, thrombocytopenia if left untreated

–Bat/bird droppings vector; usually farmers or spelunkers

Back 34

Histplasmosis

Front 35

–Foamy alveolar exudate
–Fungus
–CD4+ <200 mm3

Back 35

Pneumocystis jirovecii





(formerly: carinii)