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27 Cards in this Set
- Front
- Back
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What pathway do NSAIDS work on?
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COX
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What the selective COX-21 inhibitors
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Celebrex (celcoxib), Vioxx (rofecoxib), Bextra (valdecoxib)
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What are the NSAIDS with the least nephrotoxicity?
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COX-2's, Relafen, Lodine
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What effects to NSAIDS have on asthma
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NSAIDS can increase the symptoms of Asthma.
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What NSAIDS are safest for someone with ASTHMA?
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Diclofenac, Ketoprofen
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What NSAIDS do not inhibit platelet aggregation?
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COX-2 inhibitors
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Which treat collagen vascular disease?
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Ibuprofen, tolmenting, sulindac
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Which NSAIDS have the least effect on cardiovascular?
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Diclfenac, ketoprofen
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What NSAIDS do not decrease the chance of a DVT post-surgery?
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COX-2 inhibitors (because they do not inhibit platelet aggregation)
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What NSAIDS are the most hepatotoxic?
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Ibuprofen, naprosyn, sleve, declofenac
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What are the indications for Vioxx?
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Osteoarthritis, rheumatoid arthritis, menstrual cramps (Note: double check this)
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Most common side effect for NSAIDS?
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GI disturbance (except with COX-2 inhibitors)
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What is the only IV NSAID
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Ketorolac tromethamine (toradol)
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Does giving NSAIDS IV decrease the GI disturbances?
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No, because NSAIDS still inhibt COX-1. COX-1 has cytoprotective agents.
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What do you give for an indomethacin overdose?
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Benadryl (decreases serotonin and histamine release)
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What is an arthrotec?
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Misoprotol and diclofenac (an NSAID with protection for the stomach, not used much after cox-2 inhibitors came out)
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What is the anti-inflammatory dose of ibuprofen
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1200-3200 mg/day in divided doses
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What NSAIDS work on both the lipoxygenase and cyclooxygenase pathway?
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Ketoprofen and diclofenac
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What is the difference between cataflam and voltaren?
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Cataflam is declofenac K+ and immediate release
Voltaren is dicclfenac Na+ and delayed release |
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What is the only nonacidic NSAID?
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Nabumentone, _______
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Which NSAIDS have fewer pulmonary problems?
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Ketoprofen and diclofenac
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Which NSAIDS only have anti-inflammatory effects?
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Indomethacin, tolmenting sodium
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Do NSAIDS decrease joint destruction?
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No they only decrease inflammation
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What NSAID causes irreversible inhibition of platelet aggregation?
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Aspirin
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What are some once a day NSAIDS
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Rofecoxib (vioxx)
celebrex (clecoxib) piroxicam (feldene) oxaprozin (daypro) nabumentone (relafen) bextra (valdecoxib) more |
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What are three mechanisms of action for most NSAIDS?
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analgesic
antipyretic anti-inflammatory |
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What drugs do NSAIDS interact with and what are the effects?
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Coumadin - increases action of coumadin
Sulfonylureas - increases actio nof sulfonylurea Corticosteroids - increases antiepileptic toxicity antihypertensive meds - antagonizes antihypertensive meds Digoxin - increases digoxin's effects Methotrexate - decreases methotrexate's clearance Lithium - decreases lithium's clearance Probenecid - increases concentration of NSAIDS |
