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11 Cards in this Set
- Front
- Back
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How do you treat acute and chronic gout?
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Acute:
colchicine NSAIDS - indomethacin Corticosteroids ACTH Chronic: colchicine (prophylcatically) Allopurinol Urosurics (probenecid solfinpyrazole) |
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Stages of Gout
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1. Asympotomatic Hyperuricemia
2. acute gouty arthritis 3. intercritical gout 4. chronic gouty tophaceous gout |
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Can you use allopurinol, probenecid, or slfinpyrazole for acute gout?
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No, because they may cause an initial hyperuemia
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How do you test for gout?
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uric acid level (normal is under 7mg/dL)
aspirate the joint and send to pathology (gold standard) |
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What is a positive test for gout in pathology?
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Monosodium urate crystals are needle shaped and display a negative bifringence under a polarizing light microscope
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For gout how do you tell if someone is an overproducer or underexreter?
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TAke a 24 hour urinalysis
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Which is more common to be - an undrxcreter or an overproducer?
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Underexreters make up about 90%
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What different medicines would you give a pt with gout depending on whether he was an underexcretor or overproducer?
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overproducer --> allopurinol
Underexcreter --> probenecid OverAchieving, UnderPaid |
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What is a martini sign?
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For gout --> histo shows glucophage engulphing crystal (looks like martini and olive)
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What do you send specimen in if you suspect gout?
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alchoho, because formaldehyde dissolves gouty tophi.
If you're really not sure if it's gout you could send 2 specimens, one in normal formaldehyde and one in gout, but I'm not sure if there's any point to that. |
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What is the daily max dose of colchicine?
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PO 8 mg, IV 4mg
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