Crbohydrates: Hmp Shunt, Gluconeogeneis, Glycogenolysis

Front 1

White muscle

Back 1

Anaerobic

Front 2

Red slow twitch

Back 2

Aerobic

Front 3

Glycoge"s core protein

Back 3

Glycogenin

Front 4

Rate limiting step of glycogen synthesis

Back 4

Glycogen synthase

Front 5

Glycogen synthase in liver: activation inhibition?

Back 5

Insulin, Inhibited by glucagon, epinephrine

Front 6

Glycogen synthase in Skeletal Muscle: activation inhibition?

Back 6

Insulin, inhibited by epinephrine

Front 7

Glycogen phosphorylase in in liver: activation inhibition?

Back 7

Activation: Glucagon, epi Inhibition: Insulin

Front 8

Glycogen phosphorylase in Skeletal muscle: activation inhibition?

Back 8

Inhibited:insulin ATP, Activated: Epinephrine, AMP, Ca2+

Front 9

Von Gierke

Back 9

Glucose 6-Phosphatase deficiency

Front 10

Pompe

Back 10

Lysosomal a1-4 glucosidase

Front 11

Cori

Back 11

Debranching

Front 12

Anderson

Back 12

Branching enzyme

Front 13

Mcardle

Back 13

Muscle phosphorylase

Front 14

Hers

Back 14

Hepatic phosphorylase

Front 15

Cardiomegaly

Back 15

Pompe

Front 16

Death at 2 years

Back 16

Anderson, Pompe

Front 17

Myoglobinuria

Back 17

McArdle's

Front 18

Severe hypoglycemia

Back 18

Von Gierke's

Front 19

Mild hypoglycemia

Back 19

Cori, Hers

Front 20

Infantile hypotonia

Back 20

Cori's

Front 21

Muscle weakness

Back 21

McArdles's

Front 22

Protuding abdomen, emaciated, doll ike facies

Back 22

Von-Gierke

Front 23

Glycogen like material in inclusion bodies

Back 23

Pompe

Front 24

Glycogen structure abnormal

Back 24

Cori, Anderson

Front 25

Why mild hypoglycemia in Hers?

Back 25

Gluconeogenisis still works

Front 26

Does administration of fructose, galactose epinehrine glucagonlead to increase in blood glucose of Von Gierke Disease?

Back 26

No

Front 27

Improves at second wind, 10-15 minutes after exercise?

Back 27

McArdle

Front 28

McArdles improves by sucrose drink?

Back 28

Yes, increses glucose available

Front 29

Similar to tay sachs/I cell

Back 29

pompe

Front 30

Gluconeogeneisis sole source of glucose

Back 30

after 24 hours

Front 31

ketogenic aa?

Back 31

Leucine, lysine

Front 32

Can glucose be produced by acetyl CoA/fatty acids?

Back 32

No

Front 33

Can glucose be produced by Odd chain fattty aciD?

Back 33

Yes, they yeild small amount of propionyl-CoA

Front 34

If acytl CoA cant produce glucose, its fate?

Back 34

Fatty acid synthesis

Front 35

Pyruvate Carboxylase and pyruvate dehydrogenase controlled by..?

Back 35

Acetyl CoA

Front 36

Increased NADH, consequences

Back 36

Increased lactate, malate, Glycerol 3-P

Front 37

The amount of NADH in a cell is very tiny.. example

Back 37

MArathon runner, drinks beer after exercise, dies of lactate acidosis

Front 38

Functions of HMP shunt

Back 38

1. Production NADPH 2) Ribose 5-Phosphate

Front 39

G6PDH induced by

Back 39

Insulin, NADp

Front 40

G6PDH inhibited by

Back 40

NADPH

Front 41

The only thiamine requiring enzyme

Back 41

Transketolase

Front 42

Functions of NADPH

Back 42

Biosynthesis, ROS, PMN bactericidal activity

Front 43

Biosynthesis of..

Back 43

Chlestrol fatty acid, nucleosides

Front 44

ROS..

Back 44

Maintaining supply of reduced Glutathione

Front 45

BActericidal acticity..

Back 45

In PMN, NADPH oxidase uses it to generate H2O2

Front 46

G6PDH deficiency

Back 46

Hemolytic anemia, Heinz Bodies, Immunodeficiency

Front 47

CGD

Back 47

NADPH oxidase deficiency